Nanoencapsulation of Betamethasone Valerate Using High Pressure Homogenization-Solvent Evaporation Technique: Optimisation of Formulation and Process Parameters for Efficient Dermal Targeting.

Nanoencapsulation of Betamethasone Valerate Using High Pressure Homogenization-Solvent Evaporation Technique: Optimisation of Formulation and Process Parameters for Efficient Dermal Targeting. Drug Dev Ind Pharm. 2018 Nov 08;:1-32 Authors: Md S, Kuldeep Singh JKA, Waqas M, Pandey M, Choudhury H, Habib H, Hussain F, Hussain Z Abstract Betamethsone valerate (BMV), a medium potency topical corticosteroid, is one of the most commonly employed pharmacological agents for the management of atopic dermatitis (AD) in both adults and children. Despite having remarkable pharmacological efficacy, these agents have limited clinical implication due to poor penetration across the startum cornum (SC). To mitigate issues related to targeted delivery, stability, and solubility as well as to potentiate therapeutic and clinical implication, the nanodelivery systems have gained remarkable recognition. Therefore, the present study was aimed to encapsulate BMV into the chitosan nanoparticles (CS-NPs) for optimum dermal targeting and improved penetration across the SC. The prepared NPs were characterised for particle size, zeta potential, polydispersity index (PDI), entrapment efficiency, loading capacity, crystallinity, thermal behaviour, morphology, in vitro release kinetics, drug permeation across the SC, and percentage of drug retained into various skin layers. Results showed that optimised BMV-CS-NPs exhibited optimum physicochemical characteristics in...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research