Lichen planopilaris: Retrospective study on the characteristics and treatment of 291 patients.

Lichen planopilaris: Retrospective study on the characteristics and treatment of 291 patients. J Dermatolog Treat. 2018 Nov 09;:1-28 Authors: Babahosseini H, Tavakolpour S, Mahmoudi H, Balighi K, Teimourpour A, Ghodsi SZ, Abedini R, Ghandi N, Lajevardi V, Kiani A, Kamyab K, Mohammadi M, Daneshpazhooh M Abstract Lichen planopilaris (LPP) is an immune-mediated cicatricial alopecia. The main clinical presentations of LPP include classic form, frontal fibrosing alopecia (FFA), and Graham-Little-Piccardi-Lassueur syndrome (GLPLS). We reviewed medical records of all 291 patients diagnosied with LPP from 2006 to 2017 in Department of Dermatology, Tehran University of Medical Sciences. LPP was more common in women than men. Lichen planus (LP) was seen in 59 of patients (20.3%). Parietal lesions (69.75%), frontal (27.14%), occipital (23.71%), and temporal (21.64%) were frequently seen in LPP patients. However, trunk hair involvement (15.4% vs. 2.7%; P-value = 0.011) and eyebrow involvement (57.7% vs. 0%; P-value < 0.0001) were high in FFA patients. Patients treated with cyclosporine (CSP) achieved partial response (PR) and complete response (CR) faster than with methotrexate (MTX) and mycophenolate mofetil (MMF, P-value=0.0001). So,, CSP and MTX can be considered as effective alternative treatments for non-responders. Moreover, MTX was more effective than MMF but not different in time to reach PR (P-value=0.23) or CR (P-value=0.56)...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research