Role of pigment epithelium-derived factor (PEDF) on arsenic-induced neuronal apoptosis.

In this study of 151 adults with normal, mild, moderate, and high exposure to arsenic, the measured serum PEDF levels were 15.46 ± 5.87 ng/mL, 17.33 ± 8.22 ng/mL, 19.43 ± 9.51 ng/mL and 21.65 ± 14.46 ng/mL, respectively. Multiple linear regression analysis revealed an independent positive correlation between serum PEDF levels and arsenic exposure in drinking water. To study the underlying mechanism of arsenic-induced apoptosis, we exposed PEDF-transfected PC12 cells to NaAsO2. We discovered that NaAsO2--induced mitochondrial apoptosis was enhanced in cells that over expressed PEDF. Moreover, p53 up regulated modulator of apoptosis (PUMA) gene and B-cell lymphoma 2 (Bcl-2) protein were primary factors in the progression of arsenic-induced apoptosis. Taken together, our results suggest that PEDF inhibition might mitigate arsenic toxicity to nerve cells.
PMID: 30408888 [PubMed - in process]

Source: Chemosphere - November 10, 2018 Category: Chemistry Authors: Zhang W, Cui X, Gao Y, Sun L, Wang J, Yang Y, Liu X, Li Y, Guo X, Sun D Tags: Chemosphere Source Type: research