Comparison of biocompatibility in polysulfone dialysis membranes with different sterilization

In this study, the comparison was made between two PSf membranes in order to evaluate the effect of sterilization from the biocompatibility point of view.Methods: We investigated the biocompatibility of the following two dialyzers, that is, APS ‐11SA (Asahi Kasei medical Co., Tokyo, Japan), sterilized by gamma‐ray irradiation, and RENAK PS‐1.0 (Kawasumi laboratories, Tokyo, Japan), sterilized by autoclave. Heparin of 40 units/mL was put in a syringe, and test blood was collected from healthy volunteers. Then, the dialyzer and blood c ircuit were filled with the test blood. Subsequently, the blood was circulated by a roller pump at the rate of 200 mL/min. We measured the platelet counts, CD41 and CD42b platelet surface markers, beta‐thromboglobulin (beta‐TG) and platelet factor 4 (PF4) at 30, 120, and 240 minutes, respectivel y.Findings: The platelet counts at 30, 120, and 240 minutes decreased significantly from the initiation of blood circulation in both dialyzers. The average beta ‐TG and PF4 increased from 61.3 ± 22.1 and 17.0 ± 6.4 ng/mL to 680.7 ± 217.1 and 550.7 ± 116.7 ng/mL with APS‐11SA and to 454.3 ± 85.6 and 402.0 ± 58.0 ng/mL with RENAK PS‐1.0, respectively. The average expression of CD41 and CD42b in APS‐11SA and RENAK PS‐1.0 was similar.Discussion: There are some reports that the gamma ‐ray irradiation changes the membrane structure of the PSf membrane, crosslinking the polyvinylpyrrolidone (PVP), a...
Source: Hemodialysis International - Category: Hematology Authors: Tags: Original Article Source Type: research

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Publication date: Available online 6 December 2019Source: American Journal of Kidney DiseasesAuthor(s): Yu-Ji Lee, Yusuke Okuda, John Sy, Yong Kyu Lee, Yoshitsugu Obi, Seong Cho, Joline L.T. Chen, Anna Jin, Connie M. Rhee, Kamyar Kalantar-Zadeh, Elani StrejaRationale &ObjectivePatients receiving twice-weekly or less-frequent hemodialysis (HD) may need to undergo higher ultrafiltration rates (UFRs) to maintain acceptable fluid balance. We hypothesized that higher UFRs are associated with faster decline in residual kidney function (RKF) and a higher rate of mortality.Study DesignRetrospective cohort study.Setting &Pa...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
CONCLUSION: Remote ischemic preconditioning did not modify irisin or troponin I expression, independent of the time of collection. PMID: 31799981 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
American Journal of Roentgenology, Ahead of Print.
Source: American Journal of Roentgenology - Category: Radiology Authors: Source Type: research
End-stage renal disease (ESRD) patients experiencing kidney failure typically require hemodialysis in order to artificially remove fluid and waste from blood and maintain appropriate electrolyte concentrations. For many patients on hemodialysis, an a...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Vascular Surgery Source Type: blogs
Condition:   End Stage Renal Disease Intervention:   Other: Presence of elbow pain in patients with end stage renal disease Sponsor:   Namik Kemal University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsWith regard to KT patients and sterile wound dressing fixation with non-sterile bandages versus the use of autoclaved bandages, fixation with autoclaved bandages proved to be effective for cutaneous mucormycosis outbreak control and prevention in our institution.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Conclusion: Type II (immune complex) CGN was most common type followed by type V (immune negative) and type III (pauci-immune) CGN. The crescentic GN had worse prognosis with>80% of patients progressed to ESRD within 3 month of time from onset of illness. Early diagnosis and treatment is associated with favourable outcome. PMID: 31793263 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: CKD-MBD is common among patients on hemodialysis in our center. Screening for CKD-MBD and appropriate use of phosphate binder and Vitamin D when indicated are highly recommended.
Source: Annals of African Medicine - Category: African Health Authors: Source Type: research
CONCLUSIONS: The adaptation of the AAQ-II questionnaire to the HD context led to a valid and reliable measurement of PI in these types of patients and our results also seem to support the relationship between PI and health and quality of life parameters in patients with chronic conditions. PMID: 31791655 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Condition:   ESRD Intervention:   Device: PEPA Sponsor:   Theradial Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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