Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein ‐2

ConclusionsMetformin attenuates diabetes ‐induced renal medullary tissue hypoxia in an animal model of insulinopenic type 1 diabetes. The results suggest that the mechanistic pathway to attenuate the diabetes‐induced medullary hypoxia is independent of blood glucose homeostasis and includes reduced UCP2‐mediated mitochondrial proton LEAK.

Source: Diabetes/Metabolism Research and Reviews - November 8, 2018 Category: Endocrinology Authors: Michael Christensen, Tomas A. Schiffer, H åkan Gustafsson, Søren Palmelund Krag, Rikke Nørregaard, Fredrik Palm Tags: RESEARCH ARTICLE Source Type: research