Dopaminergic degeneration induces early posterior cortical thinning in Parkinson's disease.

DISCUSSION: To date, posterior cortical alterations in PD, known to play a major role in the development of PD-dementia, have mainly been attributed to a cholinergic degeneration occurring in later stages of the disease. Our results suggest that dopamine loss also promotes posterior-cortical atrophy from the very early stages of Parkinson's disease, which may have potential clinical and therapeutic implications. PMID: 30408592 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30408592?dopt=Abstract

Source: Neurobiology of Disease - November 5, 2018 Category: Neurology Authors: Sampedro F, Marín-Lahoz J, Martínez-Horta S, Pagonabarraga J, Kulisevsky J Tags: Neurobiol Dis Source Type: research