The Antioxidant Activity of Recombinant Rat Hepatic Fatty Acid Binding Protein T94A Variant.

CONCLUSIONS: The T94A has antioxidant activity in both hydrophilic and lipophilic environments. The T94A variant of FABP1 does not have a loss of function in regard to acting as an antioxidant but the extent of function may be influenced by ligand binding. We conclude that populations having the minor T94A allele frequency would have similar ROS scavenging potential as those with nascent FABP1.
PMID: 30407907 [PubMed - in process]

Source: J Pharm Pharm Sci - November 10, 2018 Category: Drugs & Pharmacology Authors: Le T, Gong Y, Davies NM, Lillico R, Lakowski T, Roberts MS, Burczynski FJ Tags: J Pharm Pharm Sci Source Type: research