Rumex alveollatus hydroalcoholic extract protects CCL4-induced hepatotoxicity in mice

This study was carried out to explore the protective effects ofRumex alveollatus L. on the liver damage induced by CCl4 in mice. In this experimental study, 30 male mice (35  ± 4) were divided into five groups, each with six mice. The negative control group was administered 0.5-ml olive oil; positive control group was administered 2-ml/kg CCl4 plus olive oil at 1:1 ratio for 4  days, and the experimental groups were administered 2 ml/kg CCl4 andRumex alveollatus L. extract at 150, 300, and 450  mg/kg for 4 days. All administrations were done intraperitoneally. Twenty days later, blood samples were taken from the heart, and liver serum enzymes (ALT, AST, and ALP) were measured. After sacrificing the samples, liver samples were fixed in formalin to prepare the histological sections. Then, factors such as liver volume, hepatocytes, sinusoids, central veins, portal vein, bile duct, and hepatic artery were measured.Rumex alveollatus L. extract (450  mg/kg) reduced the serum level of all three liver enzymes (p <  0.05). At this dose, the volume of sinusoids, hepatocytes, and bile duct decreased significantly (p <  0.05), but the volume of portal vein and central vein increased significantly (p <  0.05).Rumex alveollatus L. extract has protective effects against CCl4-induced damages in the liver.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research