P098 - Renal cell carcinoma with venous thrombus in metastatic patients at diagnosis, should surgery be offered?
Publication date: November 2018Source: European Urology Supplements, Volume 17, Issue 14Author(s): M. Manso, L. Pacheco-Figueiredo, A. Santos-Silva, J. Silva, C. Silva, F. Cruz
Vena cava thrombus is one of the main clinical manifestations of locally aggressive renal cell carcinoma (RCC). Inferior vena cava (IVC) wall invasion and presence of bland thrombus could affect the surgical o...
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 11Author(s): V. Atduev, D. Ledyaev, Y. Lyubarskaya, Z. Amoev, A. Danilov, G. Sheyikhov, M. Guhar Mohamed Ali, V. Bel’skiy, P. Rykhtik
To compare the perioperative and oncologic outcomes associated with open vs. robot assisted radical nephrectomy with tumor thrombus (RNTT). Renal cell carcinoma with venous tumor thrombus has traditionally been managed through an open surgical approach.. The robot assisted approach may offer improved perioperative outcomes compared to open, but there are few studies comparing these two.
Conclusion: MRI staging of RCC is an accurate predictor of the surgical and pathological stage and has the potential to become a useful tool for preoperative identification of patients with RCC who can undergo NSS.
Background/ Aim: We evaluated surgical outcomes following nephrectomy and thrombectomy with and without presurgical treatment with pazopanib in patients with advanced renal cell carcinoma with inferior vena caval tumor thrombosis. Materials and Methods: We compared surgical outcomes between patients undergoing presurgical treatment with pazopanib vs. surgery-alone in 19 patients who underwent surgery for advanced renal cell carcinoma with high-level inferior vena caval tumor thrombosis at the Kobe University Hospital. Results: Comparing the presurgical group with the surgery-alone group, respectively, the average operative...
ConclusionThe prevalence of PUWT was 10% and most cases were thought to be caused by temporary vascular dilatation in the pelvis and ureter, which is a secondary condition caused by hypervascular RCC, and not a direct result of tumor invasion.
CONCLUSION: Cavoscopy is a technique that improves detection of tumor remnants after thrombectomy in comparison to indirect review methods. Although oncological impact of caval thrombus is controversial, the use of cavoscopy allows a more complete resection of the thrombus, and it may offer a possible increase in the recurrence-free survival of these patients. PMID: 31579032 [PubMed - in process]
Front Cover Caption: The cover image is based on the Original ArticlePulmonary tumor embolization as early manifestation in patients with renal cell carcinoma and tumor thrombus: Perioperative management and outcomes by Giuseppe Serena et al.,https://doi.org/10.1111/jocs.14182.
The aim of the study was to report the experience and outcomes of Xp11.2 translocation renal cell carcinoma (tRCC) patients with tumor thrombus undergoing radical nephrectomy and thrombectomy. Between January 2017 and December 2017, 66 consecutive patients with RCC and venous thrombus involvement received surgical treatment at Peking University Third Hospital. Of which, 5 patients were confirmed of Xp11.2 tRCC, 61 patients were diagnosed of non-tRCC subtypes including 45 ccRCCs, 10 pRCCs, and 6 other subtypes. Demographic, clinical, operation, pathological and follow-up data were extracted for analysis. Prognostic factors...
ConclusionAlthough RCC with IVC tumor thrombus complicated by PTE may not be catastrophic in most cases, it appears to be associated with an increased risk of developing metastatic disease. In addition, as the PTEs appear to contain neoplastic cells, pulmonary artery embolectomy at the time of nephrectomy should be performed whenever possible.