Janssen licenses cancer drug from Yuhan 

Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research

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This study examined whether instrumented gait and balance could determine the magnitude of deterioration in motor-performance from chemotherapy-induced peripheral neuropathy (CIPN).MethodsWe recruited 84 adults with cancer (age = 71.1 ± 9.7 years old, BMI = 26.8 ± 6.2 kg/m2, gender = 56%female) and 57 age-matched non-cancer patients (age = 69.5 ± 9.8 years old, BMI = 27.1 ± 6.0 kg/m2, gender = 79%female). Based on clinical screening, the group with cancer was classified into two groups: participants with CIPN (CIPN+) and without CIPN (CIPN-). Gait ...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Authors: Wang X, Zhu H, Xu D Abstract PMID: 30657285 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
CONCLUSIONS: Saffron administration may provide some experimental evidence for the inhibitory effect of saffron on the proliferation of QGY-7703 cells, suggesting that saffron may have potential utility for the treatment of liver cancer. PMID: 30657284 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Publication date: Available online 19 January 2019Source: The Veterinary JournalAuthor(s): K.C. Pinello, J. Niza-Ribeiro, L. Fonseca, A.J. de MatosAbstractLymphoma is one of the most common neoplasms in dogs and it is one of the top five causes of cancer-related deaths, similar to human lymphoma. Companion animal epidemiological studies define dogs as sentinels of potential risk factors for human health, mainly due to shared environments, shorter disease latencies, and spontaneous disease. The aims of this study were to describe human and canine epidemiologic features of non-Hodgkin’s lymphoma (NHL) and their similar...
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Publication date: Available online 19 January 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Mabrouka Doghman-Bouguerra, Enzo LalliAbstractER-mitochondria contact sites represent hubs for signaling that control mitochondrial biology related to several aspects of cellular survival, metabolism, cell death sensitivity and metastasis, which all contribute to tumorigenesis. Altered ER-mitochondria contacts can deregulate Ca2+ homeostasis, phospholipid metabolism, mitochondrial morphology and dynamics. MAM represent both a hot spot in cancer onset and progression and an Achilles' heel of canc...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Publication date: Available online 18 January 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Polly Zhang, Adam Schatz, Babatunde Adeyemi, David Kozminski, JoEllen Welsh, Martin Tenniswood, Wei-Lin Winnie WangAbstractVitamin D3 and its receptor are responsible for controlling energy expenditure in adipocytes and have direct roles in the transcriptional regulation of energy metabolic pathways. This phenomenon also has a significant impact on the etiology of prostate cancer (PCa). Using several in vitro models, the roles of vitamin D3 on energy metabolism and its implication in primary, early ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: 25 February 2019Source: Chemico-Biological Interactions, Volume 300Author(s): Dhanaraj Teekaraman, Sugantha Priya Elayapillai, Mangala Priya Viswanathan, Arunakaran JagadeesanAbstractOvarian cancer is the leading cause of gynaecology related cancer death worldwide. It is often diagnosed with an advanced stage. Apoptosis is a process of programmed cell death controlled by cell cycle machinery and several signaling pathways. Plant-derived compounds have received an increased interest in the treatment of cancer. Quercetin is a flavonoid present in fruits and vegetables which possess anticancer properties. Se...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: 15 April 2019Source: Sensors and Actuators B: Chemical, Volume 285Author(s): Zheng Yang, Chun Yi, Sijia Lv, Yuhao Sheng, Wei Wen, Xiuhua Zhang, Shengfu WangAbstractHuman papillomavirus (HPV) type 16 is widely distributed in population, which is responsible for more than 50% of cervical cancers. A point-of-care testing for HPV16 is critical for early diagnosis and decisions regarding patient care. In this work, a novel lateral flow strip biosensor (LFSB) has been established by a simple, low-cost and green synthetic procedure for the detection of HPV16 DNA. Copper oxide nanoparticles (CuO NPs) were used as...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 19 January 2019Source: Inorganica Chimica ActaAuthor(s): Santosh Kumar, Raj Pal Sharma, Paloth Venugopalan, Valeria Ferretti, Michel Tarpin, Stéphanie Sayen, Emmanuel GuillonAbstractFive new copper(II) niflumate complexes, [Cu(en)2(nif)2], 1, [Cu(unsym-dmen)(nif)2], 2, [Cu(pn)2(nif)2][Cu(pn)2(H2O)2](nif)23, [Cu(β-pic)2(nif)2], 4, [Cu(γ-pic)2(nif)2] 5 (where en =ethylenediamine, pn = propan-1,3-diamine, unsym-dmen = unsymmetrical 1,1-dimethyl- ethylenediamine, β -pic = 3-methylpyridine, γ -pic = 4-methylpyridine, nif = niflumate) have been synthesized by using ...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: 15 April 2019Source: Chemical Engineering Journal, Volume 362Author(s): Qianqian Sun, Fei He, Huiting Bi, Zhao Wang, Chunqiang Sun, Chunxia Li, Jiating Xu, Dan Yang, Xiangxi Wang, Shili Gai, Piaoping YangAbstractCombination therapy involves the design of one unit with various therapeutic effects, such as simultaneous photothermal therapy (PTT), chemotherapy and photodynamic therapy (PDT), to produce high therapeutic efficacy with minimized side effects. Here, we designed a single near-infrared (NIR) light induced tri-mode (PTT, PDT and chemotherapy) combined therapeutic nanoplatform (named IONCs@Ce6-DOX/P...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
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