Janssen licenses cancer drug from Yuhan 

Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research

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This study aims to investigate whether the combination of CFL and 5-fluorouracil could reduce FAK protein level and iCa2+ and enhance p21 level. Furthermore, it is necessary to evaluate the response to treatment with new cancer therapeutic agents. After 24 hours of treatment, it was necessary to assess the percentage of apoptosis, FAK, and p21 protein expression by flow cytometry. iCa2+ concentration was measured using immunofluorescence. The combination therapy of CFL with 5-fluorouracil potently suppressed six treatment groups were included in this study. HT-29 cell lines were cultured and divided into six groups: group ...
Source: The Scientific World Journal - Category: Science Tags: ScientificWorldJournal Source Type: research
Conclusions: These results indicate that the economic impact of NCDs and mental health conditions is substantial and that interventions to reduce the prevalence of chronic conditions in countries of Latin America and the Caribbean are likely to be highly cost-beneficial. PMID: 31093047 [PubMed]
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
Authors: Kushwaha JP, Baidya D, Patil S Abstract Harmine (HM), a phytoconstituent has wide range of pharmacological activities including antimicrobial, antifungal, antioxidative and anticancer. HM has shown promising anticancer activity against liver cancer cells. However, poor aqueous solubility, multidrug pump P-gp efflux, extensive in vivo metabolism and rapid elimination due to glucuronidation/sulfation limits clinical utility of HM. In order to overcome the drawbacks of HM, the current work reports preparation of HM loaded galactosylated pluronic F-68 (PF68)-Gelucire® 44/14(GL44) mixed micelles (HM-MM). 32...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
ConclusionSNB application after PST for breast cancer in node positive patients at presentation is increasing. Pre-operative axillary imaging and tumour biology help identify patients who might be candidates for SNB as a single staging procedure.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 17 May 2019Source: Reumatología Clínica (English Edition)Author(s): Francisco Javier Nóvoa Medina, Delvys Rodríguez Abreu
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Publication date: Available online 18 April 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Mahesh ShettyOnce a pelvic mass is identified on an ultrasound examination, the first step in the differential diagnostic work up is to determine its origin. Most lateral pelvic masses in women are ovarian in origin, and the distinction between ovarian and nonovarian mimics of ovarian cancer is critical for appropriate clinical and surgical management. Adnexal masses detected on ultrasound can be further characterized by magnetic resonance imaging (MRI) when needed. Superior contrast resolution, multiplanar imaging, charact...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Publication date: May 2019Source: Journal of Comparative Pathology, Volume 169Author(s): S. de Brot, L. Grau-Roma, C. Stirling-Stainsby, M. Dettwiler, F. Guscetti, D. Meier, T. Scase, B.D. Robinson, D. Gardner, N.P. MonganSummaryCanine urothelial carcinoma (UC) is the most common type of cancer of the lower urinary tract and tends to affect elderly neutered female dogs, with a high predisposition for Scottish terriers. Tumour stroma, inflammation and necrosis are poorly characterized in canine UC and their role as prognostic factors is unknown. The aims of this study were to (1) assess histologically 381 canine UCs, with e...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Publication date: Available online 17 May 2019Source: Brain, Behavior, and ImmunityAuthor(s): Kyle A. Sullivan, Savannah R. Bever, Daniel B. McKim, Jonathan P. Godbout, John F. Sheridan, Karl Obrietan, Leah M. PyterAbstractCircadian rhythms influence various aspects of biology, including hormonal, immunological, and behavioral processes. These 24-hour oscillations are necessary to optimize cellular functions and to synchronize these processes with the environment. Breast cancer patients and survivors frequently report disruptions in circadian oscillations that adversely affect quality-of-life, including fragmented sleep-wa...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
BOWEL cancer symptoms can be difficult to spot, as they don ’t necessarily make you feel ill. These are the most common warning signs of bowel cancer to look out for. Could you be at risk of a deadly tumour?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 17 May 2019Source: The Lancet HaematologyAuthor(s): Jacob D Soumerai, Ai Ni, Mohamed Darif, Anil Londhe, Guan Xing, Yong Mun, Neil E Kay, Tait D Shanafelt, Kari G Rabe, John C Byrd, Asher A Chanan-Khan, Richard R Furman, Peter Hillmen, Jeffrey Jones, John F Seymour, Jeffrey P Sharman, Lucille Ferrante, Mehrdad Mobasher, Thomas Stark, Vijay ReddySummaryBackgroundClinically validated prognostic models for overall survival do not exist for patients with relapsed or refractory chronic lymphocytic leukaemia (CLL) who are on targeted therapies. We aimed to create a prognostic model to identify ...
Source: The Lancet Haematology - Category: Hematology Source Type: research
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