Involvement of neutral sphingomyelinase in the angiotensin II signaling pathway.

Involvement of neutral sphingomyelinase in the angiotensin II signaling pathway. Am J Physiol Renal Physiol. 2014 Oct 29;:ajprenal.00079.2014 Authors: Bautista-Pérez R, Del Valle-Mondragón L, Cano-Martínez A, Pérez-Méndez O, Escalante B, Franco M Abstract The possibility that angiotensin II (Ang II) exerts its effects through the activation of neutral sphingomyelinase (nSMase) has not been tested in kidneys. The results of the present study provide evidence for the activity and expression of nSMase in rat kidneys. In isolated perfused rat kidney, Ang II-induced renal vasoconstriction was inhibited by GW4869, an inhibitor of nSMase. We used nSMase for investigating the signal transduction downstream of ceramide. nSMase constricted the renal vasculature. An inhibitor of ceramidase (CDase), N-oleoylethanolamine (OEA), enhanced either Ang II or nSMase-induced renal vasoconstriction. To demonstrate the interaction between the nSMase and cytosolic phospholipase A2 (cPLA2) signal transduction pathways, we evaluated the response to nSMase in the presence and absence of inhibitors of arachidonic acid metabolism: arachidonyl trifluoromethyl ketone (AACOCF3), an inhibitor of cPLA2; 5,8,11,14-eicosatetraynoic acid (ETYA), an inhibitor of all AA pathways; indomethacin, an inhibitor of cyclooxygenase (COX); furegrelate, a thromboxane A2 (TXA2) -synthase inhibitor; and SQ29548, a TXA2-receptor antagonist. In these experiments, the nSM...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

Related Links:

Authors: Stefano GB, Esch T, Kream RM Abstract The relaxation response derives its health benefits by reestablishing "normal" equilibria between the sympathetic and parasympathetic branches of the autonomic nervous system. Recent work suggests that this behavioral training provides positive effects on mitochondrial bioenergetics, insulin secretion, and reductions in pro-inflammatory and stress-related pathways. We have previously contended, however, that correlative associations of relaxation training with positive changes in gene expression in selected biological systems are strongly suggestive of adapti...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Xu J, Wang X, Xiao H, Xu J Abstract BACKGROUND To determine the difference in size-specific dose estimates (SSDEs), separately based on effective diameter (deff) and water equivalent diameter (dw) of the central slice of the scan range in computed tomography coronary angiography (CTCA). MATERIAL AND METHODS There were 134 patients who underwent CTCA examination, were electronically retrieved. SSDEs (SSDEdeff and SSDEdw) were calculated using 2 approaches: deff and dw. The median SSDEs and mean absolute relative difference of SSDEs were calculated. Linear regression model was used to assess the absolute rel...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway. Med Sci Monit. 2019 Dec 06;25:9290-9298 Authors: Shang X, Lin K, Yu R, Zhu P, Zhang Y, Wang L, Xu J, Chen K Abstract BACKGROUND Sepsis combined with myocardial injury is an important cause of septic shock and multiple organ failure. However, the molecular mechanism of sepsis-induced myocardial dysfunction has not yet been thoroughly studied. Resveratrol has been an important rese...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Pountney M PMID: 31809596 [PubMed - in process]
Source: Medicine, Conflict and Survival - Category: International Medicine & Public Health Tags: Med Confl Surviv Source Type: research
Authors: Birch M, van Bergen L PMID: 31809595 [PubMed - in process]
Source: Medicine, Conflict and Survival - Category: International Medicine & Public Health Tags: Med Confl Surviv Source Type: research
This study assessed the prevalence, risk factors, and co-infectivity of CTBP such as piroplasms, rickettsiae, Coxiella burnetii, hepatozoa, hemotropic mycoplasmas, and Borrelia spp., using PCR and phylogenetic analyses. Of the 510 dogs tested, three CTBP, including Anaplasma phagocytophilum 16S rRNA (13; 2.6%), Hepatozoon canis 18S rRNA (2; 0.4%), and Mycoplasma haemocanis 16S rRNA (1; 0.2%) were detected. PCR adapted to amplify A. phagocytophilum msp2 and groEL genes generated amplicons thereof in two out of 13 positive dogs. One shelter dog was co-infected with A. phagocytophilum and M. haemocanis. However, Ehrlichia spp...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 6 December 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Hein Sprong, Sander Moonen, Sipke E. van Wieren, Tim R. HofmeesterAbstractCattle grazing has been suggested to reduce the risk for Lyme borreliosis by decreasing the density of questing Ixodes ricinus infected with Borrelia burgdorferi sensu lato. We tested the hypotheses that cattle grazing used in woodland management decreases the density of questing I. ricinus, and that it decreases the nympal infection prevalence of B. burgdorferi sensu lato. We further expected the nympal infection prevalence of tick-borne pathogens that ...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 6 December 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Amber M. Frye, Thomas M. Hart, Danielle M. Tufts, Sanjay Ram, Maria A. Diuk-Wasser, Peter Kraiczy, Anna M. Blom, Yi-Pin LinAbstractComplement is a key first line innate host defense system in the blood of vertebrates. Upon activation, this powerful defense mechanism can elicit inflammatory responses, lyse non-self-cells, or mark them for opsonophagocytic removal. Blood-feeding arthropods thus require the ability to block host complement activation in the bloodmeal to prevent undesired cell or tissue damage during feeding. The ...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
"TAVI: Valve in Valve. A new field for structuralists? Literature review". Hellenic J Cardiol. 2019 Dec 03;: Authors: Vrachatis DA, Vavuranakis M, Tsoukala S, Sotiria G, Papaioannou TG, Siasos G, Deftereos G, Giannopoulos G, Raisakis K, Tousoulis D, Deftereos S, Vavuranakis M Abstract Transcatheter aortic valve implantation (TAVI) literally founded the structural heart interventions subspecialty and created an emerging journey of clinical and technical issues. Soon after TAVI introduction into clinical practice, boundaries were expanded with utilization of valve-in-valve (V-i-V) techniques. V...
Source: Hellenic Journal of Cardiology - Category: Cardiology Tags: Hellenic J Cardiol Source Type: research
Transparent substrates introduce challenges in optical metrology, recording, and microscopy. Backside reflections reduce signal to noise, ...
Source: Optics Letters - Category: Physics Authors: Source Type: research
More News: Indomethacin | Study | Urology & Nephrology