The utility of anti-SOX2 antibodies for cancer prediction in patients with paraneoplastic neurological disorders

Antibodies to SOXB1 proteins in patients with paraneoplastic disorders are associated with small-cell lung cancer (SCLC), particularly in Lambert-Eaton myasthenic syndrome (LEMS). We aimed to establish if SOX2 antibodies could be used to identify SCLC and other tumours found in a range of paraneoplastic disorders and controls.SOX2 antibodies were detectable in 61% of patients with LEMS-SCLC, and in other paraneoplastic disorders, such as opsoclonus-myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC.

Source: Journal of Neuroimmunology - November 8, 2018 Category: Allergy & Immunology Authors: Paul Maddison, Maarten J. Titulaer, Jan J. Verschuuren, Paul Gozzard, Bethan Lang, Sarosh R. Irani, Lidia Sabater, Francesc Graus, Andrea Murray, Caroline J. Chapman Source Type: research