Update in the Management of Chronic Hepatitis B in Pregnancy

AbstractPurpose of ReviewVertical transmission accounts for almost half of the chronic hepatitis B infections worldwide. Therefore, management of HBV in pregnancy presents a unique opportunity for intervention, so that vertical transmission and overall HBV could be reduced. There is limited data on outcomes of acute HBV. There were several observational and prospective studies on effects of chronic HBV during pregnancy, modes of mother to child transmission (MTCT), role of obstetric interventions, indications for antiviral therapy during pregnancy which demonstrated variable findings. Our purpose is to summarize and update the data published in the recent years on the topic.Recent FindingsPregnant women with acute HBV had fewer symptoms but were prone to become chronic HBV carriers compared to non-pregnant women with acute HBV infection. HBV transmission could occur at any time during pregnancy via germ cell, intra-uterine, or peri-natal transmission. Avoidance of invasive procedures during pregnancy and elective Cesarean section have shown evidence in minimizing the risk of MTCT. Antiviral therapy during third trimester at 30 –32 weeks of gestation in pregnant mothers with high viremia>  200,000 IU/mL was associated with significantly lowered risk of MTCT. Among lamivudine, telbivudine, and tenofovir that are considered safe during pregnancy, tenofovir is the preferred drug of choice due to higher resistance barrier and efficacy. Immuno-prophylaxis ...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research

Related Links:

Oman Med J. 2021 Jul 31;36(4):e287. doi: 10.5001/omj.2021.99. eCollection 2021 Jul.ABSTRACTOBJECTIVES: Hepatitis B virus (HBV) is a major public health problem worldwide. The prevalence of HBV is dependent on the modes of transmission. Chronic hepatitis B (CHB) infection can progress to liver cirrhosis and hepatocellular carcinoma. Oman is regarded as an intermediate endemic region and has had a neonatal vaccine against HBV since 1990. However, little research has been conducted regarding risk factors for HBV transmission. Our study aimed to identify the prevalence of major risk factors for acquiring HBV in Oman.METHODS: W...
Source: Oman Medical Journal - Category: Middle East Health Authors: Source Type: research
Conclusions In Turkey, the prevalence of hepatitis and HIV was not found as high as endemic regions of the world. It is essential to identify the infection of hepatitis and HIV for the treatment, follow-up, and fetal infection in the pregnancy.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Original Articles Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
This study aimed to determine the viral hepatitis in pregnant women attending antenatal clinic, AMTHI. Informed consent questionnaire was administered before blood collection via venipuncture. a total of 904 pregnant women plasma samples were tested for HBV, HCV, and HEV using ELISA kit. Data was analyzed using packages within SPSS software and P ≤ 0.05 was considered significant. Out of 904 samples analyzed, the overall prevalence of hepatitis infections among pregnant women attending antenatal clinic in AMTHI was 66(7.3%). High prevalence of the hepatitis infections was found among young women within the age grou...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research
ConclusionIn addition to active and passive immunoprophylaxis, lamivudine, telbivudine and tenofovir in highly viremic mothers can further decrease MTCT of HBV. Based on direct and indirect evidence, tenofovir appears to be more effective than the two other drugs in the prevention of HBV MTCT.
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Infectious hepatitis in pregnancy is clinically significant in both the acute and chronic phases. Here, we review the perinatal implications of chronic hepatitis B and C and acute hepatitis A and E. Familiarity with screening, transmission, diagnosis, and management of infectious hepatitis is of ongoing importance during obstetric care, as these diseases are endemic in much of the world. Pregnancy and interpregnancy care provide opportunities to prevent infection and transmission of hepatitis.
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Liver Disease in Pregnancy Source Type: research
AbstractChina has the world's largest burden of hepatitis B virus (HBV) infection, but the country has made considerable progress in preventing its mother-to-child transmission (MTCT) in the past three decades. This feat is made possible due to the high coverage of birth-dose hepatitis B vaccine (HepB,> 95%), hepatitis B surface antigen (HBsAg) screening for pregnant women (> 99%), and hepatitis B immunoglobulin plus HepB for newborns whose mothers are HBsAg positive (> 99%). Studies on the optimal antiviral treatment regimen for pregnant women with high HBV-DNA load have also been conducted. However, China still ...
Source: Frontiers of Medicine - Category: General Medicine Source Type: research
This study confirms that hepatitis E is the leading cause of acute jaundice, leads to hospitalizations in all regions in Bangladesh, occurs throughout the year, and is associated with considerable morbidity and mortal ity. Effective control measures should be taken to reduce the risk of HEV infections including improvements in water quality, sanitation and hygiene practices and the introduction of HEV vaccine to high-risk groups.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ConclusionsHBV prevalence in Dolpo is significantly higher than in the rest of Nepal. Targeted interventions are recommended to address liver and sexual health education, including the introduction of birth dose HBV vaccinations, HBV screening and HBV vaccinations for pregnant women in Dolpo.
Source: Journal of Public Health - Category: Health Management Source Type: research
In countries where hepatitis B virus (HBV) is endemic, including Senegal, the World Health Organization recommends systematic HBV screening of pregnant women and vaccination at birth to prevent mother-to-child...
Source: BMC Health Services Research - Category: General Medicine Authors: Tags: Research article Source Type: research
More News: Antiviral Therapy | Cesarean Section | Children | China Health | Endemics | Hepatitis | Hepatitis B | Hepatitis Vaccine | Infectious Diseases | OBGYN | Pregnancy | Study | Vaccines | Viread | Women