Lower sarcoplasmic reticulum Ca2+ threshold for triggering afterdepolarizations in diabetic rat hearts

Type-2 diabetes (T2D) increases the arrhythmias risk through incompletely elucidated mechanisms. Ventricular arrhythmias could be initiated by delayed afterdepolarizations (DADs) resulting from elevated spontaneous sarcoplasmic reticulum (SR) Ca2+ release (SR Ca2+ leak).

Source: Heart Rhythm - November 7, 2018 Category: Cardiology Authors: Iuliana Popescu, Guo Yin, Sathya Velmurugan, Jeffrey R. Erickson, Florin Despa, Sanda Despa Source Type: research