New, more accessible staging system developed to predict survival for patients with AL Amyloidosis

(Boston Medical Center) A new staging system developed with a more accessible test to predict the chance of survival in patients living with light chain (AL) amyloidosis.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

Related Links:

Authors: Chen L, Luodelete M, Dong C, Li B, Zhang W, Nie P, Liu J, Chen X, Luo P Abstract Background: To investigate the pathological spectrum of glomerular disease in patients with renal insufficiency (RI) from 2008 to 2017. Methods and results: We calculated the estimated glomerular filtration rate (eGFR) with the Chronic Kidney Disease Epidemiology Collaboration creatinine (CKD-EPI) equation and defined RI as an eGFR
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Systemic amyloidosis is a devastating group of disorders for which there is no current cure. The treatment goal is to reduce the burden of amyloidogenic protein precursors. The treatment is only effective if a...
Source: Diagnostic Pathology - Category: Pathology Authors: Tags: Short report Source Type: research
Amyloid deposition of WT human β2-microglobulin (WT-hβ2m) in the joints of long-term hemodialysis patients is the hallmark of dialysis-related amyloidosis. In vitro, WT-hβ2m does not form amyloid fibrils at physiological pH and temperature unless co-solvents or other reagents are added. Therefore, understanding how fibril formation is initiated and maintained in the joint space is important for elucidating WT-hβ2m aggregation and dialysis-related amyloidosis onset. Here, we investigated the roles of collagen I and the commonly administered anticoagulant, low-molecular-weight (LMW) heparin, in the initia...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research
Publication date: Available online 12 June 2019Source: Urology Case ReportsAuthor(s): Puja Patel, Mohammad Pourmandi, Jeffrey S. LombardAbstractPrimary amyloidosis of the bladder is a rare clinical occurrence, with only a limited number of cases documented in literature thus far. Herein, is the presentation of a case involving a 75 year old male who presented with painless gross hematuria. Subsequent laboratory results and imaging completed were misleading, creating a high suspicion for bladder malignancy. Further workup revealed bladder biopsies to have positive apple-green birefringence with Congo-red immunostaining, dia...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Conditions:   Valve Stenoses, Aortic;   Amyloidosis Cardiac Intervention:   Diagnostic Test: Diagnosis of amyloidosis Sponsor:   Javier López Pais Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Amyloidosis Intervention:   Diagnostic Test: Amyloidosis typing using mass spectrometry-based proteomics Sponsors:   University Hospital, Toulouse;   Proteomics and Mass Spectrometry of Biomolecules, Proteomics Infrastructure of Toulouse Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Valve Stenoses, Aortic;   Amyloidosis Cardiac Intervention:   Diagnostic Test: Diagnosis of amyloidosis Sponsor:   Javier López Pais Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Amyloidosis Intervention:   Diagnostic Test: Amyloidosis typing using mass spectrometry-based proteomics Sponsors:   University Hospital, Toulouse;   Proteomics and Mass Spectrometry of Biomolecules, Proteomics Infrastructure of Toulouse Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Valve Stenoses, Aortic;   Amyloidosis Cardiac Intervention:   Diagnostic Test: Diagnosis of amyloidosis Sponsor:   Javier López Pais Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Amyloidosis Intervention:   Diagnostic Test: Amyloidosis typing using mass spectrometry-based proteomics Sponsors:   University Hospital, Toulouse;   Proteomics and Mass Spectrometry of Biomolecules, Proteomics Infrastructure of Toulouse Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Amyloidosis | International Medicine & Public Health