Familiar music could give Alzheimer's patients a cognitive boost, study suggests

It's long been known that Alzheimer's patients often retain musical memories, even when they can't remember names, faces or places. Canadian researchers say brain scans have helped them understand why.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news

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(Beth Israel Deaconess Medical Center) In a study published today in the journal BRAIN, neuroscientists led by Michael D. Fox, M.D., Ph.D., of Beth Israel Deaconess Medical Center (BIDMC) used data from the human brain connectome -- a publicly available 'wiring diagram' of the human brain based on data from thousands of healthy human volunteers -- to reassess the findings from neuroimaging studies of patients with Alzheimer's disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Individuals with mild cognitive impairment (MCI) exhibit varying serial position effect (SPE) performances. The relationship between SPE performance in word list recall and clinical, genetic, and neuroimaging features of MCI requires elucidation. 119 MCI and 68 cognitively normal (CN) participants underwent cognitive assessment, apolipoprotein E (ApoE) genotyping, and volumetric MRI brain scans processed via voxel-based morphometry. A 10-word recall task was used to assess SPE performance in relation to recency and primacy recall. MCI participants were classified as having Good SPE performance (high prima...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Researchers from Johns Hopkins University have developed a new brain scan that uses radioactive 'tracer' molecules to 'light up' plaques that are responsible for cognitive decline in patients.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 11 December 2018Source: NeuroImage: ClinicalAuthor(s): Thomas D. Parker, Catherine F. Slattery, Keir X.X. Yong, Jennifer M. Nicholas, Ross W. Paterson, Alexander J.M. Foulkes, Ian B. Malone, David L. Thomas, David M. Cash, Sebastian J. Crutch, Nick C. Fox, Jonathan M. SchottAbstractThe most common presentation of early onset Alzheimer's disease (EOAD – defined as symptom onset
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 6 December 2018Source: NeuroImageAuthor(s): Claire Cury, Stanley Durrleman, David M. Cash, Marco Lorenzi, Jennifer M. Nicholas, Martina Bocchetta, John C. van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B. Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Sebastien OurselinAbstractBrain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as front...
Source: NeuroImage - Category: Neuroscience Source Type: research
Beta secretase (BACE) inhibitors are promising therapeutic compounds currently in clinical phase II/III trials. Preclinical [18F]-florbetaben (FBB) amyloid PET imaging facilitates longitudinal monitoring of amyloidosis in Alzheimer's disease (AD) mouse models. Therefore, we applied this theranostic concept to investigate, by serial FBB PET, the efficacy of a novel BACE1 inhibitor in the PS2APP mouse, which is characterized by early and massive amyloid deposition.Methods: PS2APP and C57BL/6 (WT) mice were assigned to treatment (PS2APP: N=13; WT: N=11) and vehicle control (PS2APP: N=13; WT: N=11) groups at the age of 9.5 mon...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusion: We believe this study greatly expands the applications of silk fibroin-based materials, is an important contribution to the advancement of biomaterials, and would also be valuable in the design of new types of multichannel electrochemical immunosensor arrays for the detection of other diseases.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Publication date: 1 February 2019Source: NeuroImage, Volume 186Author(s): Abhijit Guha Roy, Sailesh Conjeti, Nassir Navab, Christian Wachinger, Alzheimer's Disease Neuroimaging InitiativeAbstractWhole brain segmentation from structural magnetic resonance imaging (MRI) is a prerequisite for most morphological analyses, but is computationally intense and can therefore delay the availability of image markers after scan acquisition. We introduce QuickNAT, a fully convolutional, densely connected neural network that segments a MRI brain scan in 20 s. To enable training of the complex network with millions of learnable paramet...
Source: NeuroImage - Category: Neuroscience Source Type: research
(Society of Nuclear Medicine and Molecular Imaging) Tau tangles in the brain are markers of Alzheimer's disease and are also potential therapy targets. A study featured in the December issue of The Journal of Nuclear Medicine reports on the identification of a promising second-generation positron emission tomography (PET) tracer for imaging and measuring tau pathology, contributing to understanding of Alzheimer's and related dementias. The new research featured in the December 2018 issue of The Journal of Nuclear Medicine.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This case study investigates the association of regional in vivo retention of the tau positron emission tomography ligand [18F]flortaucipir with the density of tau neuropathology in the corresponding brain regions in a patient with early-onset Alzheimer disease caused by aPSEN1 mutation.
Source: JAMA Neurology - Category: Neurology Source Type: research
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