Familiar music could give Alzheimer's patients a cognitive boost, study suggests

It's long been known that Alzheimer's patients often retain musical memories, even when they can't remember names, faces or places. Canadian researchers say brain scans have helped them understand why.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news

Related Links:

Funding Opportunity RFA-AG-20-043 from the NIH Guide for Grants and Contracts. This funding opportunity will support a new, centralized infrastructure (U24) to aggregate, harmonize, manage, and share existing and future neuroimaging data collected in NIA- supported Alzheimer's Disease Research Centers (ADRCs).
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
In this study, we aimed to study the Tau PET images in these patients. Methods Clinical features, brain magnetic resonance imaging/computed tomography (MRI/CT), and brain 18F-THK-5351 PET were recorded in five patients with the APP p.D678H mutation and correlated with brain 18F-AV-45 PET images. We also compared the tau deposition patterns among five patients with familial mild cognitive impairment (fMCI), six patients with sporadic amnestic mild cognitive impairment (sMCI), nine patients with mild to moderate dementia due to Alzheimer’s disease (AD), and 12 healthy controls (HCs). All of the subjects also recei...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: Available online 18 May 2019Source: NeuroImageAuthor(s): Bernadet L. Klaassens, Joop M.A. van Gerven, Erica S. Klaassen, Jeroen van der Grond, Serge A.R.B. RomboutsAbstractDisruption of cholinergic and serotonergic neurotransmitter systems is associated with cognitive, emotional and behavioural symptoms of Alzheimer's disease (AD). To investigate the responsiveness of these systems in AD we measured the effects of a single-dose of the selective serotonin reuptake inhibitor citalopram and acetylcholinesterase inhibitor galantamine in 12 patients with AD and 12 age-matched controls on functional brain conne...
Source: NeuroImage - Category: Neuroscience Source Type: research
DiscussionOur results encourage an independent validation cohort study to confirm the indication that the plasma Aβ1–40/Aβ1–42 ratio, assessed via Simoa, may improve future standard of care and clinical trial design.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
DISCUSSION: Quantification of 18F-florbetaben positron emission tomography scans using magnetic resonance-based and magnetic resonance-less CapAIBL® approaches showed high agreement, establishing a pathology-based threshold in CL. PMID: 31101517 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Authors: Yu HL, Chen ZJ, Zhao JW, Duan SR, Zhao JK Abstract PURPOSE: The aim of this study was to evaluate the relationship between olfactory function and hippocampal volume in patients with mild cognitive impairment (MCI). METHODS: We enrolled a total of 31 MCI patients and 9 normal control subjects. All participants underwent 3.0 T-magnetic resonance imaging scanning. The scan results were processed using GE ADW4.6 processing software and V0xar 3D workstation to acquire the hippocampal volume. The University of Pennsylvania Smell Identification Test (UPSIT) was used to evaluate the olfactory function o...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
AbstractWe performed this research to 1) evaluate a novel deep learning method for the diagnosis of Alzheimer ’s disease (AD) and 2) jointly predict the Mini Mental State Examination (MMSE) scores of South Korean patients with AD. Using resting-state functional Magnetic Resonance Imaging (rs-fMRI) scans of 331 participants, we obtained functional 3-dimensional (3-D) independent component spatial maps for use as features in classification and regression tasks. A 3-D convolutional neural network (CNN) architecture was developed for the classification task. MMSE scores were predicted using: linear least square regressio...
Source: Neuroinformatics - Category: Neuroscience Source Type: research
DiscussionQuantification of 18F-florbetaben positron emission tomography scans using magnetic resonance–based and magnetic resonance–less CapAIBL® approaches showed high agreement, establishing a pathology-based threshold in CL.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Conclusion: The typical deposition of 18F-AV1451 tau PET imaging in AD brain was found in amygdala, entorhinal cortex, fusiform and parahippocampus, and they were strongly associated with cognitive impairment and CSF biomarkers. 18F-AV-1451 PET imaging could not differentiate the MCI from CN population. More tau deposition related to decreased MMSE score and increased CSF p-tau level . PVC improved the results of tau deposition and correlation studies in small brain regions and suggested to be routinely used in 18F-AV1451 tau PET quantification.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Severe worry is a transdiagnostic symptom that is associated with increased risk of conversion to Alzheimer ’s disease and increased risk of cardiovascular events. There is a need to develop treatments that are effective in reducing worry in older adults. We investigated the neural basis of worry induction and reappraisal using a personalized worry task.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
More News: Alzheimer's | Brain | Canada Health | Health | Neurology | PET Scan | Study