Researchers have unlocked secrets about engineered protein receptor, CAR

(University of Southern California) Three USC Viterbi School of Engineering researchers -- Assistant Professor Stacey Finley, Professor Pin Wang and Assistant Professor Nick Graham -- have just published a paper in 'Biophysical Journal' that sheds light on Chimeric Antigen Receptor (CAR) T cell therapy, information that could one day result in better cancer therapies with fewer side effects.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells — which can give rise to every cell type in the body and which can be grown indefinitely in the lab — into becoming mature T cells capable of killing tumor cells.The technique uses structures called artificial thymic organoids, which work by mimicking the environment of the thymus, the organ in which T cells develop from blood stem cells.T cells are cells of the immune system that fight infections, but also have the potential to eliminate cancer cells. The ability to create them from self-renewing pluripotent ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
CONCLUSIONS Our study reveals that RTHF-mediated inhibition of DUBs and proteasome may provide a potential strategy for cancer therapy. PMID: 30643111 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
With advances in cancer therapy, diseases that were once fatal are becoming chronic disorders, often with adverse endocrine effects.Medscape Diabetes &Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Commentary Source Type: news
Cancer therapy decisions are often made according to the histopathological-molecular profile of tumor tissue obtained from surgery or biopsy. It has been shown that tumor profiles change with time and treatment, and that tumor tissue is heterogeneous. Thus, other approaches that are easily accessible and less invasive than surgery or biopsy to monitor responses to treatment and predict relapses are urgently needed. In the last few years, the term “liquid biopsies” has been introduced to represent multifunctional circulating biomarkers in the peripheral blood and other physiological fluids of patients with cance...
Source: Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 16 January 2019Source: Materials Science and Engineering: CAuthor(s): Catarina A. Reis, Carolina F. Rodrigues, André F. Moreira, Telma A. Jacinto, Paula Ferreira, Ilídio J. CorreiaAbstractCancer is one of the major world public health problems and the currently available treatments are nonspecific and ineffective. This reality highlights the importance of developing novel therapeutic approaches. In this field, multifunctional nanomedicines have the potential to revolutionize the currently available treatments. These unique nanodevices can simultaneously act as therapeutic an...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
(Natural News) It has been 16 years since the human genome was decoded — an accomplishment that scientists hoped would someday prove useful in cancer therapy. There was an optimistic, if not naive, belief that we could simply “switch off” cancer-causing genes. Nevertheless, oncologists are still encountering problems with this concept more than a decade...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
r Robert Lukowski Several tumor entities have been reported to overexpress KCa3.1 potassium channels due to epigenetic, transcriptional, or post-translational modifications. By modulating membrane potential, cell volume, or Ca2+ signaling, KCa3.1 has been proposed to exert pivotal oncogenic functions in tumorigenesis, malignant progression, metastasis, and therapy resistance. Moreover, KCa3.1 is expressed by tumor-promoting stroma cells such as fibroblasts and the tumor vasculature suggesting a role of KCa3.1 in the adaptation of the tumor microenvironment. Combined, this features KCa3.1 as a candidate target for inn...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.8b00836
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
This study assessed gynecologists ’ and embryologists’ current practice, knowledge, and attitude concerning fertility preservation (FP) in cancer survivors. This current survey was performed on a convenience sample of 277 gynecologists and embryologists who attended large international congresses held across Iran. A 23-item self -administered questionnaire that included questions on knowledge, attitudes, and practice was used. Questions had either yes/no responses, or were answered based on a 4-point (1 to 4) Likert scored scale. Total mean score for knowledge of all FP options was 2.97 ± 0...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression o...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Review Source Type: research
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