Philips to shut down Respironics facility in Kennesaw, affecting hundreds

Philips Respironics makes sleep and respiratory products and services for managing sleep apnea, oxygen therapy, noninvasive ventilation and respiratory drug therapy.
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news

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Conclusion: Women had longer RTL and a higher step count compared to men. However, exercise volume and RTL correlated positively only in men. Surprisingly, age correlated negatively with RTL already within an age difference of 2 years. This suggests that telomere attrition rate may accelerate in older age. Moderate physical activity at the time of study was associated with RTL. Introduction Telomeres are looped structures located at the end of chromosomes, protecting our genomic DNA from degradation. Telomeric DNA consists of repetitive sequences of TTAGGG, common to all mammals (Aubert and Lansdorp, 2008). Double-...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health probl...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
AbstractIntroductionObstructive sleep apnea (OSA) may have prothrombotic effects.ObjectiveTo investigate the effect of OSA on disease severity, pulmonary artery thrombus load, and prognosis in patients with acute pulmonary embolism (PE).MethodsIn 101 PE patients, disease severity was determined by the simplified PE severity index (sPESI) score, pulmonary artery thrombus load was quantified by the pulmonary artery obstruction index (PAOI), and sleep-disordered breathing was evaluated by nocturnal polygraphy.ResultsObstructive sleep apnea patients with an apnea –hypopnea index (AHI) ≥ 15/h cohort were ...
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
AbstractPurpose of ReviewThis review seeks to highlight the issue of when the best time to operate is given the neurocognitive consequences of pediatric OSA.Recent FindingsLearning and memory deficits persist after adenotonsillectomy in school age children with the disease at 9-month follow-up, suggesting short-term damage to the hippocampus in young children with OSA.SummaryLarger trials with younger children with pediatric OSA are currently ongoing to evaluate the impact of adenotonsillectomy on learning and memory recovery.
Source: Current Anesthesiology Reports - Category: Anesthesiology Source Type: research
Abstract Background: Obstructive sleep apnea (OSA) is a common disease. It can cause many serious complications. OSA may increase the risk of hypertension. However, the exact mechanism of OSA causing hypertension is not fully understood. YKL-40/chitinase-3-like protein-1 plays an important role in vascular injury, repair, and generation. We sought to explore the role of YKL-40 in endothelial dysfunction and hypertension in OSA patients. Methods: All subjects were examined by polysomnography (PSG) and the expression of YKL-40 in the plasm of the subjects was measured by luminex. Carotid intima-media thickness ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
The objective of this study was to examine the association of objective sleep with cognitive performance in MCI patients. A subsample of 271 participants with a diagnosis of probable Alzheimer's disease (AD; N = 50) or mild cognitive impairment (MCI; N = 121) and 100 persons who were not cognitively impaired (NI) were recruited from a large population-based cohort in the island of Crete, Greece (3140 older adults aged>60 years). All participants underwent extensive neuropsychiatric/neuropsychological evaluation and a 3-day 24-hr actigraphy. Objective sleep variables and their association with ne...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
Obese people with sleep apnea may live longer with positive airway pressure (PAP) therapy, a recent study suggests.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news
Authors: Bilotta F, Giordano G, Pugliese F PMID: 30997176 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Comment to the Editorial by KS Park and EW Kang "Is only fixed positive airway pressure a robust tool for kidney protection in patients with obstructive sleep apnea?" J Thorac Dis. 2019 Mar;11(Suppl 3):S480-S482 Authors: Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR PMID: 30997253 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Kalkbrenner C, Brucher R, Kesztyüs T, Eichenlaub M, Rottbauer W, Scharnbeck D Abstract The current gold standard for assessment of most sleep disorders is the in-laboratory polysomnography (PSG). This approach produces high costs and inconveniences for the patients. An accessible and simple preliminary screening method to diagnose the most common sleep disorders and to decide whether a PSG is necessary or not is therefore desirable. A minimalistic type-4 monitoring system which utilized tracheal body sound and actigraphy to accurately diagnose the obstructive sleep apnea syndrome was previously develo...
Source: GMS German Medical Science - Category: General Medicine Tags: Ger Med Sci Source Type: research
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