Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea: A pilot study

Publication date: March 2019Source: Schizophrenia Research: Cognition, Volume 15Author(s): Hannah Myles, Nicholas Myles, Ching Li Chai Coetzer, Robert Adams, Madhu Chandratilleke, Dennis Liu, Jeremy Mercer, Andrew Vakulin, Andrew Vincent, Gary Wittert, Cherrie GalletlyAbstractPrevious studies have shown that people with schizophrenia have high rates of Obstructive Sleep Apnoea (OSA). Despite this, intervention studies to treat OSA in this population have not been undertaken. The ASSET (Assessing Sleep in Schizophrenia and Evaluating Treatment) pilot study investigated Continuous Positive Airway Pressure (CPAP) treatment of severe OSA in participants recruited from a clozapine clinic in Adelaide. Participants with severe untreated OSA (Apnoea-Hypopnoea Index (AHI) > 30), were provided with CPAP treatment, and assessed at baseline and six months across the following domains: physical health, quality of sleep, sleepiness, cognition, psychiatric symptoms and CPAP adherence. Six of the eight ASSET participants with severe OSA accepted CPAP. At baseline, half of the cohort had hypertension, all were obese with a mean BMI of 45, and they scored on average 1.47 standard deviations below the normal population in cognitive testing. The mean AHI was 76.8 and sleep architecture was markedly impaired with mean rapid eye movement (REM) sleep 4.1% and mean slow wave sleep (SWS) 4.8%. After six months of treatment there were improvements in cognition (BACS Z score improved by an average ...
Source: Schizophrenia Research: Cognition - Category: Psychiatry Source Type: research