PGC-1 α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes

Conclusion: CIHH treatment could reduce the calcium overload and H/R injury in cardiomyocytes by up-regulating the expression of PGC-1 α and regulating the energy metabolism of glucose and lipid. The HIF-1α-AMPK signaling pathway might be involved in the process.Cell Physiol Biochem 2018;50:1891 –1902
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research