Higher BMI Linked to Lower Brain Volume in MS Higher BMI Linked to Lower Brain Volume in MS

Researchers report that higher BMI is linked to lower brain volume in multiple sclerosis. A second study links healthy eating to better measures of disability, mobility, and cognitive function.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Related Links:

We present the results from the two-phases of our prospective study on cognitive decline in MS patients using the data collected from the A' Neurologic clinic at AHEPA hospital, Thessaloniki, Greece. Most of the patients of the present study revealed mild cognitive impairment with mild influence on the everyday function. We found weak correlation between cognitive deficit and the duration of MS, as well as the physical disability status and moderate correlation between cognitive impairment and the type of the disease as well as MRI findings (atrophy and lesion load). Our results also indicate that the currently available b...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Publication date: Available online 14 September 2017Source: NeuroImageAuthor(s): Massimo Filippi, Paolo Preziosa, Maria A. RoccaAbstractThe application of structural and functional magnetic resonance imaging (MRI) techniques in patients with multiple sclerosis (MS) has certainly helped to improve our understanding of the mechanisms responsible for clinical disability and cognitive impairment in this condition.The numerous studies performed in MS patients have also provided many lessons on the structure-function relationships in the human brain, which could be applied to healthy subjects and to patients affected by other ne...
Source: NeuroImage - Category: Neuroscience Source Type: research
The objectives of this study were 1) to assess the prevalence of work absence shortly after MS diagnosis, 2) to explore health-related quality of life (HRQoL) and disease impact in relation to work absence and 3) to investigate demographic and clinical factors that may be associated with high work absence.MethodsPatients with relapsing remitting (RRMS) or primary progressive MS (PPMS) were included shortly after MS diagnosis. We collected data on work absence due to MS in the year prior to inclusion, disability (Expanded Disability Status Scale), relapse rate, fatigue (Neurological Fatigue Index), health-related quality of...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 14 March 2019Source: The Lancet NeurologyAuthor(s): Valery L Feigin, Emma Nichols, Tahiya Alam, Marlena S Bannick, Ettore Beghi, Natacha Blake, William J Culpepper, E Ray Dorsey, Alexis Elbaz, Richard G Ellenbogen, James L Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L James, Catherine Owens Johnson, Nicholas J Kassebaum, Giancarlo Logroscino, Benoît Marin, W Cliff Mountjoy-VenningSummaryBackgroundNeurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases...
Source: The Lancet Neurology - Category: Neurology Source Type: research
OBJECTIVES: To assess the prevalence and interrelationship between lower urinary tract symptoms and sexual dysfunction in men with multiple sclerosis (MS). METHODS: In a cross-sectional study, we evaluated 41 men (mean age 41.1 ±9.9 years) with MS from February 2011 to March 2013, who were invited to participate irrespective of the presence of lower urinary tract symptoms or sexual dysfunction. Neurological impairment was assessed with the Expanded Disability Status Scale; lower urinary tract symptoms were evaluated with the International Continence Society male short-form questionnaire, and sexual dysfunction was e...
Source: Clinics - Category: General Medicine Source Type: research
Axonal degeneration is related to long-term disability in patients with multiple sclerosis (MS). The underlying mechanism remains ill understood but appears to involve axonal energetic dysfunction. A globally ...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
ConclusionsRebound syndrome is an intractable complication of exit strategy for fingolimod ‐treated RRMS patients. To lower the risk for rebound syndrome, specific mechanisms of rebound syndrome are to be clarified. Furthermore, concise risk stratification for progressive multifocal leukoencephalopathy in fingolimod treatment is imperative. Taken together, the risk–benefit analysis fo r fingolimod treatment, including rebound syndrome as well as progressive multifocal leukoencephalopathy, is required to initiate the drug.
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: Case Report Source Type: research
ConclusionsMotor-predominant HDLS has characteristic frequent frontal release signs, normal findings for OCB and the IgG index, severe CC body atrophy, abundant deep and subcortical WMLs in the frontoparietal lobes, subtle occipitotemporal lobe periventricular WMLs, and more restricted diffusivity lesions on MRI. Although the present study was limited by the small number of HDLS cases, we propose that immunotherapy should be avoided in such cases.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
SAN DIEGO - A disability plan's termination of short-term disability (STD) benefits was an abuse of discretion because the plan failed to consider the claimant's subjective reports of pain related to her diagnosis of multiple sclerosis and erroneously concluded that the claimant's symptoms had improved, a California federal judge said March 4 in remanding for an award of STD benefits and for a determination on the claimant's entitlement to long-term disability (LTD) benefits (Lizbeth Valdez v. AT&T Umbrella Benefit Plan No. 1, No. 16-2613, S.D. Calif., 2019 U.S. Dist. LEXIS 34159).
Source: LexisNexis® Mealey's™ Disability Insurance Legal News - Category: Medical Law Source Type: news
ConclusionsWe confirmed the clinical and MRI efficacy of alemtuzumab in the clinical setting and the frequency of infusion-related reactions. Compared with that in clinical trials, higher number of patients developed pneumonitis during infusion.
Source: Journal of Neurology - Category: Neurology Source Type: research
More News: Brain | Disability | Health | Multiple Sclerosis | Neurology | Neurosurgery | Study