Viruses, Vol. 10, Pages 615: Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System

Viruses, Vol. 10, Pages 615: Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System Viruses doi: 10.3390/v10110615 Authors: Danielle B. L. Oliveira Giuliana S. Durigon Érica A. Mendes Jason T. Ladner Robert Andreata-Santos Danielle B. Araujo Viviane F. Botosso Nicholas D. Paola Daniel F. L. Neto Marielton P. Cunha Carla T. Braconi Rúbens P. S. Alves Monica R. Jesus Lennon R. Pereira Stella R. Melo Flávio S. Mesquita Vanessa B. Silveira Luciano M. Thomazelli Silvana R. Favoretto Franciane B. Almonfrey Regina C. R. M. Abdulkader Joel M. Gabrili Denise V. Tambourgi Sérgio F. Oliveira Karla Prieto Michael R. Wiley Luís C. S. Ferreira Marcos V. Silva Gustavo F. Palacios Paolo M. A. Zanotto Edison L. Durigon We followed the presence of Zika virus (ZIKV) in four healthy adults (two men and two women), for periods ranging from 78 to 298 days post symptom onset. The patients were evaluated regarding the presence of the virus in different body fluids (blood, saliva, urine and semen), development of immune responses (including antibodies, cytokines and chemokines), and virus genetic variation within samples collected from semen and urine during the infection course. The analysis was focused primarily on the two male patients who shed the virus for up to 158 days after the initial symptoms. ZIKV particles were detected in the spermat...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research