Homocysteine and age-associated disorders.

Homocysteine and age-associated disorders. Ageing Res Rev. 2018 Nov 01;: Authors: Ostrakhovitch EA, Tabibzadeh S Abstract There are numerous theories of aging, a process which still seems inevitable. Aging leads to cancer and multi-systemic disorders as well as chronic diseases including those that impair the functions of endothelial cells, kidney and lung. Decline in age- associated cellular functions leads to neurodegeneration and cognitive decline that affect the quality of life. Accumulation of damage, mutations, metabolic changes, failure in cellular energy production and clearance of altered proteins over the lifetime, and hyperhomocysteinemia, ultimately result in tissue degeneration. Moreover, approximately 50% of people, aged 65 years and older develop hypertension and are at a high risk of developing cardiovascular insufficiency. Dysfunctional mitochondria in aging cardiomyocytes contribute to myocardial remodeling leading to heart failure. Osteoporosis is prevalent in the elderly, making them predisposed to vertebral deformities as well as fractures of the hip, wrist and spine. Genetic factors as well as better medical care, a well balanced diet, and lack of stress increases the life expectancy. PMID: 30391754 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research