Five new alkaloids from Aconitum apetalum (Ranunculaceae)

Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Zhan-Xing Hu, Hong-Yu Tang, Xiao-Hui Yan, Yan-Rong Zeng, Haji Aker Aisa, Yu Zhang, Xiao-Jiang HaoAbstractTwenty-one alkaloids, including five new ones, acoapetaldines A–E (1–5), were isolated from the whole plants of Aconitum apetalum. Among them, 1 is an aconitine-type diterpenoid alkaloid, 2 and 3 are aporphine alkaloids and 4 and 5 are napelline-type diterpenoid alkaloids. The structures of the new alkaloids were elucidated by spectroscopic data analysis and that of acoapetaldine D (4) was confirmed by single crystal X-ray crystallography. Acoapetaldine A (1) and aconorine (12) exhibited moderate anti-tobacco mosaic virus (anti-TMV) activity, while corydine (15) displayed moderate antimicrobial activity against Pseudomonas aeruginosa.Graphical abstract

Source: Phytochemistry Letters - November 7, 2018 Category: Chemistry Source Type: research