Alterations of colonic sensitivity and gastric dysmotility after acute cisplatin and granisetron

Conclusions and InferencesCisplatin ‐induced bedding intake and gastric dysmotility were blocked by granisetron, confirming the involvement of serotonin acting on 5‐HT3 receptors. Unexpectedly, visceral sensitivity to colonic distension was reduced, to the same extent, by cisplatin, granisetron, and their combination, suggesting important mechanistic differences with nausea and gastric dysmotility that warrant further investigation.

Source: Neurogastroenterology and Motility - November 6, 2018 Category: Gastroenterology Authors: Marta Mart ín‐Ruíz, José A. Uranga, Paula Mosinska, Jakub Fichna, Kulmira Nurgali, Mª Isabel Martín‐Fontelles, Raquel Abalo Tags: ORIGINAL ARTICLE Source Type: research