FDA Grants Priority Review for Sanofi's Dengue Vaccine Candidate
BRIDGEWATER, N.J., Oct. 30, 2018 /PRNewswire/ -- The United States Food and Drug Administration (FDA) has accepted a Biologics License Application for Sanofi Pasteur's dengue vaccine. The dengue vaccine candidate has been granted priority...
Publication date: Available online 13 March 2019Source: Journal of Theoretical BiologyAuthor(s): Sourav Kumar Sasmal, Yasuhiro Takeuchi, Shinji NakaokaAbstractDengue infection results in a significant number of deaths, mostly in the tropical and subtropical regions across the world. Yet, despite the seriousness of this disease, vaccine, and antiviral drugs that could be employed in dengue treatment remain elusive. The desire to establish the factors determining the disease severity and the growing need for efficient drugs has prompted extensive research interest in within-host viral dynamics. However, very few mathematical...
asad Dash Well-developed mouse models are important for understanding the pathogenesis and progression of immunological response to viral infections in humans. Moreover, to test vaccines, anti-viral drugs and therapeutic agents, mouse models are fundamental for preclinical investigations. Human viruses, however, seldom infect mice due to differences in the cellular receptors used by the viruses for entry, as well as in the innate immune responses in mice and humans. In other words, a species barrier exists when using mouse models for investigating human viral infections. Developing transgenic (Tg) mice models expressin...
With India described as the epicenter of dengue, contributing significantly to the global dengue epidemic, the country is also poised to play a key role in contributing towards the WHO 2020 targets of reducing dengue deaths by 50% and dengue cases by 25%. This Supplement seeks to integrate research findings within India, provide a platform for dissemination of current dengue research, and encourage future dengue control activities under the leadership of the Indo-US Vaccine Action Program and the Indian government .
In this study, we investigated t he interaction of dengue viral proteins with host NMT and its subsequent effect on DENV. Our bioinformatics, molecular docking, and far‐western blotting analyses demonstrated the interaction of viral envelope protein (E) with NMT. The gene expression of NMT was strongly elevated in a dependent man ner during the viral replication phase in dendritic cells. Moreover, NMT gene silencing significantly inhibited DENV replication in dendritic cells. Further studies investigating the target cell types of other host factors are suggested.
This study provided new evidences of the molecular mechanisms of DENV virulence.
The Philippine Department of Justice on Friday said it had found probable cause to indict officials from French drugmaker Sanofi and former and current Philippine health officials over 10 deaths it said were linked to use of a dengue vaccine.
Officials say fear of vaccines after Dengvaxia scandal is main reason for measles epidemic
The Philippine Department of Justice said it will indict employees from Sanofi and former and current Philippine health officials over a series of deaths related to the French drugmaker's dengue vaccine.