Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray Neuroscience

Adequate pain management remains an unmet medical need. We previously revealed an opioid-independent analgesic mechanism mediated by orexin 1 receptor (OX1R)-initiated 2-arachidonoylglycerol (2-AG) signaling in the ventrolateral periaqueductal gray (vlPAG). Here, we found that low-frequency median nerve stimulation (MNS) through acupuncture needles at the PC6 (Neiguan) acupoint (MNS-PC6) induced an...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research

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ConclusionsDue to the high heterogeneity and poor quality of AE data, the definite characteristics of the AEs were undetermined. The heterogeneity may have occurred from differences in the strictness of AE report and safety procedural guidelines. To improve this, we summarized the drafts of safety procedural guidelines. Our findings could be used in further studies to establish MSN treatment safety.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Notice NOT-AR-19-035 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
The Journal of Alternative and Complementary Medicine, Ahead of Print.
Source: The Journal of Alternative and Complementary Medicine - Category: Complementary Medicine Authors: Source Type: research
This study will focus on detecting the cerebral functional connectivity changes elicited by acupuncture treatment. The Visual Analog Scale and the short form of the McGill Pain Questionnaire, the Western Ontario and McMaster Universities Osteoarthritis Index, the Attention Test Scale, the Pain Assessment of Sphygmomanometer and the 12-Item Short Form Health Survey will be used to evaluate the symptoms and quality of life improvement at the baseline and the end of treatment. The Self-rating Anxiety Scale and the Self-rating Depression Scale will be used at the baseline and the end of treatment to investigate the influence o...
Source: Trials - Category: Research Source Type: clinical trials
CONCLUSIONS: There is insufficient evidence to guide continence care of adults in the rehabilitative phase after stroke. As few trials tested the same intervention, conclusions are drawn from few, usually small, trials. CIs were wide, making it difficult to ascertain if there were clinically important differences. Only four trials had adequate allocation concealment and many were limited by poor reporting, making it impossible to judge the extent to which they were prone to bias. More appropriately powered, multicentre trials of interventions are required to provide robust evidence for interventions to improve urinary inco...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSION: Certain naturopathic treatments and complementary medical methods may be useful in postoperative care and deserve more intensive study. In the publications consulted for this review, no serious side effects were reported. PMID: 30678751 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
AbstractPurpose of ReviewChronic pain is a prevalent, disabling, and expensive pediatric condition. Specific treatment options have limited evidence and are often extrapolated from adult care. This review evaluates pain outcome measures, psychological treatment, pharmacologic management, multidisciplinary treatment models, and emerging topics in pediatric pain medicine.Recent FindingsMultimodal cognitive behavioral therapy and intensive interdisciplinary pain treatment have the strongest evidence for improving pain and function while decreasing healthcare utilization. There is emerging evidence that parental involvement in...
Source: Current Physical Medicine and Rehabilitation Reports - Category: Rehabilitation Source Type: research
Pain is a complex multidimensional issue compromised of physical, biochemical, neurological, nutritional, and psychosocial-spiritual components. Primary medical treatments to date habitually treat pain with pharmacologic management as first line of care, yet chronic pain management metrics have not improved. As opioid medications have recently come under intense scrutiny, certain integrative therapies such as acupuncture are now being recognized as effective for many chronic non-malignant pain syndromes, such as chronic headache and chronic low back pain.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
-Liang Ou Acupuncture is a practice of treatment based on influencing specific points on the body by inserting needles. According to traditional Chinese medicine, the aim of acupuncture treatment for pain management is to use specific acupoints to relieve excess, activate qi (or vital energy), and improve blood circulation. In this context, the Hegu point is one of the most widely-used acupoints for this purpose, and it has been linked to having an analgesic effect. However, there exists considerable debate as to its scientific validity. In this pilot study, we aim to identify the functional connectivity related to the...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
This technical assistance VideoCast is designed to aid potential grantees for RFA-AT-19-005: HEAL: Pragmatic Randomized Controlled Trial of Acupuncture for Management of Chronic Low Back Pain in Older Adults (UG3/UH3). This FOA encourages UG3/UH3 phased cooperative research applications to conduct an efficient, large-scale pragmatic trial to evaluate the impact of, and strategies to best implement, acupuncture treatment of older adults (65 years and older) with chronic low back pain. This FOA requires that the intervention under study be embedded into multiple health care delivery systems, “ real world ” settin...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
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