Protection of dilator function of coronary arteries from homocysteine by tetramethylpyrazine: Role of ER stress in modulation of BKCa channels.
CONCLUSIONS: Reversal of BKCa channel inhibition via suppressing ER stress-mediated loss of β1 subunits contributes to the protective effect of TMP against homocysteine on coronary dilator function. Inhibition of FoxO3a-dependent ubiquitin ligases is involved in TMP-conferred normalization of BKCa β1 protein level. These results provide new mechanistic insights into the cardiovascular benefits of TMP.
PMID: 30389615 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Sun WT, Wang XC, Novakovic A, Wang J, He GW, Yang Q Tags: Vascul Pharmacol Source Type: research
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