Effects of serum estradiol and progesterone on estrogen-regulated gene expression in breast cancers of premenopausal patients.

Conclusions: The serum E2 level on the day of surgery influences estrogen-regulated gene expression moderately in patients found to be strongly positive for estrogen receptor α by immunohistochemistry. Changes in serum E2 levels might influence the results of molecular profiling tests in premenopausal women with breast cancer.
PMID: 30395264 [PubMed - as supplied by publisher]

Source: Clinical Genitourinary Cancer - November 5, 2018 Category: Cancer & Oncology Authors: Wanifuchi-Endo Y, Asano T, Kondo N, Hato Y, Dong Y, Hisada T, Nishikawa S, Kato H, Takahashi S, Okuda K, Yamashita H, Toyama T Tags: Jpn J Clin Oncol Source Type: research