Characterization of the tumor immune-microenvironment of lung adenocarcinoma associated with usual interstitial pneumonia

A malignant tumor is composed of not only cancer cells but also various types of non-cancerous stromal cells containing cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), and tumor infiltrating lymphocytes (TILs); such heterogeneous population of cells gives rise to cancer-specific microenvironments [1 –5]. Recent studies have shed new light on this complex interaction between tumor and host immune cells and helped us understand the immune response triggered by this interaction.

Source: Lung Cancer - November 6, 2018 Category: Cancer & Oncology Authors: Takuya Ueda, Keiju Aokage, Sachiyo Mimaki, Kenta Tane, Tomohiro Miyoshi, Masato Sugano, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Masahiko Kusumoto, Kenji Suzuki, Katsuya Tsuchihara, Hiroyoshi Nishikawa, Koichi Goto, Masahiro Tsuboi, Source Type: research