Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model

ConclusionsIn this study,QPRT was causally related to in vitro neuronal differentiation of SH-SY5Y cells and affected the regulation of genes and gene networks previously implicated in ASD. Thus, our data suggest thatQPRT may play an important role in the pathogenesis of ASD in Chr16p11.2 deletion carriers.
Source: Molecular Autism - Category: Molecular Biology Source Type: research