AI May Detect Alzheimer's Years Before Diagnosis AI May Detect Alzheimer's Years Before Diagnosis

Onset of Alzheimer's disease occurs years before appearance of clinical symptoms. Artificial intelligence (AI) using a sophisticated PET scan algorithm facilitates early detection and diagnosis.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news

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Authors: Yu HL, Chen ZJ, Zhao JW, Duan SR, Zhao JK Abstract PURPOSE: The aim of this study was to evaluate the relationship between olfactory function and hippocampal volume in patients with mild cognitive impairment (MCI). METHODS: We enrolled a total of 31 MCI patients and 9 normal control subjects. All participants underwent 3.0 T-magnetic resonance imaging scanning. The scan results were processed using GE ADW4.6 processing software and V0xar 3D workstation to acquire the hippocampal volume. The University of Pennsylvania Smell Identification Test (UPSIT) was used to evaluate the olfactory function o...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
AbstractWe performed this research to 1) evaluate a novel deep learning method for the diagnosis of Alzheimer ’s disease (AD) and 2) jointly predict the Mini Mental State Examination (MMSE) scores of South Korean patients with AD. Using resting-state functional Magnetic Resonance Imaging (rs-fMRI) scans of 331 participants, we obtained functional 3-dimensional (3-D) independent component spatial maps for use as features in classification and regression tasks. A 3-D convolutional neural network (CNN) architecture was developed for the classification task. MMSE scores were predicted using: linear least square regressio...
Source: Neuroinformatics - Category: Neuroscience Source Type: research
DiscussionQuantification of 18F-florbetaben positron emission tomography scans using magnetic resonance–based and magnetic resonance–less CapAIBL® approaches showed high agreement, establishing a pathology-based threshold in CL.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Conclusion: The typical deposition of 18F-AV1451 tau PET imaging in AD brain was found in amygdala, entorhinal cortex, fusiform and parahippocampus, and they were strongly associated with cognitive impairment and CSF biomarkers. 18F-AV-1451 PET imaging could not differentiate the MCI from CN population. More tau deposition related to decreased MMSE score and increased CSF p-tau level . PVC improved the results of tau deposition and correlation studies in small brain regions and suggested to be routinely used in 18F-AV1451 tau PET quantification.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Severe worry is a transdiagnostic symptom that is associated with increased risk of conversion to Alzheimer ’s disease and increased risk of cardiovascular events. There is a need to develop treatments that are effective in reducing worry in older adults. We investigated the neural basis of worry induction and reappraisal using a personalized worry task.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
In conclusion, high amyloid burden was modestly associated with fewer specific words, but not with syntactic complexity or lexical complexity, suggesting that subtle spontaneous speech deficits might occur in preclinical AD.
Source: Neuropsychologia - Category: Neurology Source Type: research
CONCLUSIONS: Patients and caregivers emphasized the importance of having a dementia diagnosis and placed more value on testing and outcomes for asymptomatic populations than clinicians. This underscores the importance of research investigating the effect of amyloid PET results on asymptomatic individuals and the need for amyloid PET ordering and disclosure standards. PMID: 31058683 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Alzheimer’s is related to the buildup of amyloid plaques in the brain, so any serious attempt at dislodging these plaques may help reverse the progression of the disease. The perennial problem with delivering drug therapies to treat brain condi...
Source: Medgadget - Category: Medical Devices Authors: Tags: Neurology Radiology Rehab Source Type: blogs
This study, as well as the larger SPRINT study, also demonstrated that overall intensive treatment of blood pressure in older adults is safe. However, we do know that some individuals may develop dizziness, imbalance, and in rare instances strokes with intensive blood pressure lowering. For that reason, it is important to discuss your blood pressure management with your primary care physician and follow his or her recommendation. How do cardiovascular risk factors affect brain health? We have evidence from studies of the population, studies of brain scans, and studies of animals, that treatment of cardiovascular risk facto...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Brain and cognitive health Heart Health Hypertension and Stroke Memory Prevention Source Type: blogs
Publication date: Available online 5 May 2019Source: International Journal of PsychophysiologyAuthor(s): Benjamin M. Hampstead, Anthony Y. Stringer, Randall F. Stilla, K. SathianAbstractLearning and memory deficits characterize the diagnosis of amnestic mild cognitive impairment (aMCI), which is widely viewed as a clinical precursor to Alzheimer's type dementia. There is a growing interest in non-pharmacologic interventions, such as mnemonic strategies, for improving learning and memory in patients with aMCI as well as for maintaining functioning in healthy older adults. Using an ecologically relevant object-location assoc...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
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