AI May Detect Alzheimer's Years Before Diagnosis AI May Detect Alzheimer's Years Before Diagnosis

Onset of Alzheimer's disease occurs years before appearance of clinical symptoms. Artificial intelligence (AI) using a sophisticated PET scan algorithm facilitates early detection and diagnosis.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news

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AbstractPurposeWe investigated the regional distribution of18F-THK5351 uptake in gray (GM) and white matter (WM) in patients with behavioral-variant frontotemporal dementia (bvFTD) and compared it with that in patients with Alzheimer ’s disease (AD) or semantic dementia (SD).Methods18F-THK-5351 positron emission tomography (PET),18F-florbetaben PET, magnetic resonance imaging, and neuropsychological testing were performed in 103 subjects including 30, 24, 9, and 8 patients with mild cognitive impairment, AD, bvFTD, and SD, respectively, and 32 normal subjects. Standardized uptake value ratios (SUVRs) of18F-THK-5351 P...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
DISCUSSION: Optimized tau PET classifiers may diagnose AD with high accuracy, but both tau PET and structural brain MRI capture partly unique information relevant for the clinical deterioration in AD. PMID: 30639421 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
By Sandee LaMotte, CNN (CNN) — Here’s another reason why getting a good night’s sleep should be on your must-do list: Sleeping fewer than six hours a night or waking frequently raises your risk of developing damaging plaque in arteries throughout your body, not just your heart. Previous research has shown poor sleep to be strongly associated with coronary heart disease, but “This is the first study to show that objectively measured sleep is independently associated with atherosclerosis throughout the body,” José Ordovás, director of nutrition and genomics at the Jean Mayer USDA H...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health CNN Heart Disease Sleep Tufts University Source Type: news
Authors: Duff K, Horn KP, Hoffman JM Abstract PURPOSE: Longitudinal studies into the variability of F-Flutemetamol uptake are lacking. METHODS/PATIENTS: Therefore, the current study examined change in F-Flutemetamol uptake in 19 nondemented older adults (65 to 82 y old) who were either cognitively intact or had Mild Cognitive Impairment (MCI) who were scanned twice across 3.6 years. RESULTS: Baseline and follow-up composite SUVRs were significantly correlated (0.96, P
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Publication date: 2019Source: International Review of Neurobiology, Volume 144Author(s): Oliver Cousins, Tayyabah Yousaf, Heather Wilson, Gennaro Pagano, Marios PolitisAbstractDementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia. The core clinical features of DLB include fluctuating cognition, visual hallucinations, rapid eye movement sleep behavior disorder, and parkinsonism. Molecular imaging is a powerful tool to assess the brain function in vivo. In this chapter, we reviewed the positron emission tomography, single-photon emission computed tomography, and [123I]-metaiodobenzylgu...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 9 January 2019Source: NeuroImageAuthor(s): Yikai Wang, Ying GuoAbstractIn recent years, longitudinal neuroimaging study has become increasingly popular in neuroscience research to investigate disease-related changes in brain functions, to study neurodevelopment or to evaluate treatment effects on neural processing. One of the important goals in longitudinal imaging analysis is to study changes in brain functional networks across time and how the changes are modulated by subjects' clinical or demographic variables. In current neuroscience literature, one of the most commonly used tools to ...
Source: NeuroImage - Category: Neuroscience Source Type: research
Using MRI and PET scans and cerebrospinal fluid assays, researchers have collected...Read more on AuntMinnie.comRelated Reading: MRI offers possible link between microbleeds, Alzheimer's Brain MRI offers new insight into blood deposits New Alzheimer's definition relies on imaging biomarkers MRI technique locates areas of cognitive impairment MRI links brain leaks to Alzheimer's disease
Source: Headlines - Category: Radiology Source Type: news
African-American individuals on average have lower levels of the tau protein compared with white individuals, reports astudy published today inJAMA Neurology. Tau, along with amyloid beta, are two proteins strongly associated with Alzheimer ’s disease (AD) and considered key biomarkers for diagnosing AD.“To our knowledge, our study is the first to examine racial differences in molecular biomarkers of AD in which the cohort contributed data for both amyloid concentrations as seen on PET scan and CSF [cerebrospinal fluid] concentrations of [amyloid and tau],” wrote lead author John C. Morris, M.D ., of the ...
Source: Psychiatr News - Category: Psychiatry Tags: African Americans Alzheimer's disease amyloid beta APOE ε4 biomarkers cerebrospinal fluid. John C. Morris JAMA Neurology Lisa Barnes minorities race tau Source Type: research
Publication date: Available online 5 January 2019Source: NeuroImage: ClinicalAuthor(s): Boyd Kenkhuis, Laura E. Jonkman, Marjolein Bulk, Mathijs Buijs, Baayla D.C. Boon, Femke H. Bouwman, Jeroen J.G. Geurts, Wilma D.J. van de Berg, Louise van der WeerdAbstractUsing 7T T2⁎-weighted imaging, we scanned post-mortem hemispheres of Alzheimer patients and age-matched controls to describe the patterns of appearance of cortical lamination on T2*-weighted MRI in the medial temporal lobe and to assess the changes in Alzheimer patients versus controls. While controls showed a hypointense line of Baillarger in the majority of the ca...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
In this study we developed and performed initial validation tests of an MR-compatible phantom and analysis software for robust and reliable evaluation of the brain volume loss. The phantom contained three inflatable models of brain structures, i.e. cerebral hemisphere, putamen, and caudate nucleus. Software to reliably quantify volumes form the phantom images was also developed. To validate the method, the phantom was imaged using 3D T1-weighted protocols at three clinical 3T MR scanners from different vendors. Calculated volume change from MRI was compared with the known applied volume change using ICC and mean absolute d...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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