Joint Contributions of Rare Copy Number Variants and Common SNPs to Risk for Schizophrenia.

CONCLUSIONS:: The authors found evidence for interactive effects of PRS and previously associated CNVs for risk for schizophrenia, and the results for large deletions and total CNV burden support an additive model. These findings offer insights into the genetic architecture of schizophrenia by illuminating how different established genetic risk factors act and interact to influence liability to schizophrenia. PMID: 30392412 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30392412?dopt=Abstract

Source: The American Journal of Psychiatry - November 5, 2018 Category: Psychiatry Authors: Bergen SE, Ploner A, Howrigan D, CNV Analysis Group and the Schizophrenia Working Group of the Psychiatric Genomics Consortium, O'Donovan MC, Smoller JW, Sullivan PF, Sebat J, Neale B, Kendler KS Tags: Am J Psychiatry Source Type: research

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