Association Between Season, Temperature and Causative Organism in Microbial Keratitis in the UK

Purpose: Microbial keratitis (MK) is a major cause of corneal blindness worldwide. Variations in season and temperature can affect MK incidence due to specific causative organisms; however, few studies have examined these factors in the UK. Methods: Retrospective review of all corneal scrapes from patients with MK presenting to Manchester Royal Eye Hospital, UK, between January 2004 and December 2015. Manchester’s monthly temperature data were obtained from Met Office UK. Analysis was performed using logistic regression. Results: From 4229 corneal scrapes, 1539 organisms grew (90.6% bacteria, 7.1% fungi, and 2.3% Acanthamoebae sp.). Gram-positive bacteria grew with increasing temperature [odds ratio (OR) 1.62, 95% CI: 1.11–2.39, P = 0.014], and fungi grew with decreasing temperature (OR 0.29, 95% CI: 0.16–0.51, P
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research