Global, regional, and national burden of motor neuron diseases 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Publication date: Available online 5 November 2018Source: The Lancet NeurologyAuthor(s): Giancarlo Logroscino, Marco Piccininni, Benoît Marin, Emma Nichols, Foad Abd-Allah, Ahmed Abdelalim, Fares Alahdab, Solomon Weldegebreal Asgedom, Ashish Awasthi, Yazan Chaiah, Ahmad Daryani, Huyen Phuc Do, Manisha Dubey, Alexis Elbaz, Sharareh Eskandarieh, Farzaneh Farhadi, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Irina FilipSummaryBackgroundUnderstanding how prevalence, incidence, and mortality of motor neuron diseases change over time and by location is crucial for understanding the causes of these disorders and for health-care planning. Our aim was to produce estimates of incidence, prevalence, and disability-adjusted life-years (DALYs) for motor neuron diseases for 195 countries and territories from 1990 to 2016 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016.MethodsThe motor neuron diseases included in this study were amyotrophic lateral sclerosis, spinal muscular atrophy, hereditary spastic paraplegia, primary lateral sclerosis, progressive muscular atrophy, and pseudobulbar palsy. Incidence, prevalence, and DALYs were estimated using a Bayesian meta-regression model. We analysed 14 165 site-years of vital registration cause of death data using the GBD 2016 cause of death ensemble model. The 84 risk factors quantified in GBD 2016 were tested for an association with incidence or death from motor neuron diseases...
Source: The Lancet Neurology - Category: Neurology Source Type: research

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ConclusionThis adapted version of the Facial Disability Index in Brazilian-Portuguese was shown to be a valid and reliable tool to assess the impact of facial nerve dysfunction on the physical and psychosocial aspects of these patients.ResumoIntroduçãoParalisia facial periférica pode ocorrer devido a uma grande variedade de causas e está associada ao comprometimento de atividades diárias básicas, como comer, beber, falar e comunicação social, afetando a qualidade de vida desses pacientes. O Facial Disability Index é um questionário auto aplicado desenvol...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
In this study, zebrafish at days post fertilization treated with ethidium bromide (EB) at a concentration of 75 μM for 72 h were determined as the optimum conditions for the demyelination model development. Zebrafish motility was recorded automatically using a video-track motion detector and quantitative myelin assay was measured by FluoroMyelin staining. A well-known remyelination agent thyroxine (T4) was tested to confirm whether EB-induced motility and myelin damage could be rescued. Two RORγt lead inhibitors GSK805 and SR1001 were assessed for their therapeutic effects on remyelination, axon regeneration, ...
Source: Journal of Pharmacological and Toxicological Methods - Category: Drugs & Pharmacology Source Type: research
Discussion “Macrocephaly is defined as [an occipitofrontal circumference or head circumference, OFC ] of> 2 standard deviations above the mean or above the 97th percentage for a given age, and gender, or when serial measurement shows progressive enlargement, crossing of one or more major percentiles, or when there is an increase in OFC> 2 cm/month in the first 6 months of life.” Megalencephaly is enlargement of the brain parenchyma. The OFC should be measured using a non-elastic tape which surrounds the head along the line of the glabella and posterior occipital protrusion. There are ethnic differences f...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
PEOPLE who are diagnosed with arthritis are often affected by a functional disability at least a year or two before being diagnosed with the condition. This month is National Arthritis Awareness Month and new studies suggest the importance of early detection of the condition. Express.co.uk sheds a light on arthritis, the major symptoms to look out for and the latest research.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Brignardello-Petersen R PMID: 31101321 [PubMed - as supplied by publisher]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
[Epidemiologic study of leprosy in Brazil: reflections on elimination goalsEstudio epidemiológico de la lepra en el Brasil: reflexión sobre las metas de eliminación]. Rev Panam Salud Publica. 2018;42:e42 Authors: Ribeiro MDA, Silva JCA, Oliveira SB Abstract Objective: To describe the epidemiological profile of leprosy in Brazil in the period from 2005 to 2015 and describe the behavior of leprosy indicators in relation to the goals established by the World Health Organization (WHO) for elimination of this disease. Method: The study was performed using data from the Ministry of H...
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
Authors: Brunt D, Schröder A, Lundqvist LO, Rask M Abstract The residents' perspective of the quality of housing support for people with psychiatric disabilities living in congregate supported housing has been studied and a comparison has been made with the findings from those from a previous study in ordinary housing with outreach support. One-hundred and seventy-eight residents from 27 supported housing facilities in eight Swedish municipalities completed the Quality of Psychiatric Care-Housing (QPC-H) instrument. The highest quality ratings were found for: Secluded Environment, Encounter and Support, while ...
Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
Authors: Strilchuck L, Fogacci F, Cicero AF Abstract INTRODUCTION: Cardiovascular (CV) diseases are the leading cause of death and disability in the developed countries. Lipid-lowering therapy is a cornerstone of the CV risk modification strategy. The first line treatment for hyperlipidemia is statins, which decrease low-density lipoprotein cholesterol (LDL-C) by 30-50% and proportionally reduce the CV events. However, they are not always enough to achieve LDL-C goals in many patients, and some patients are statin intolerant. For this reason, new powerful injectable lipid-lowering drugs have been developed. Areas c...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
We read with great interest the paper entitled “Compound heterozygous SZT2 mutations in two siblings with early-onset epilepsy, intellectual disability and macrocephaly” by Domingues et al. [1].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Letter to the editor Source Type: research
Publication date: Available online 18 May 2019Source: Journal of Pharmacological SciencesAuthor(s): Ying Tang, Ming-Yue Li, Xin Zhang, Xing Jin, Jing Liu, Ping-He WeiAbstractStroke is one of the leading causes of long-term disabilities worldwide. Although exposure to an enriched environment (EE) initiated in the acute phase after stroke has neuroprotective effects and improves stroke outcome, it remains unclear whether EE has positive effects when started in a delayed time frame. Here we show that exposure to EE in the delayed phase notably ameliorates the ischemia-induced impairments in neurological functions and spatial ...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
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