Gala Therapeutics launches RheOx chronic bronchitis trial

Gala Therapeutics said today that it launched an early feasibility study of its RheOx system for treating chronic bronchitis, and that the first two patients in the trial have already been enrolled. Initial patient enrollment took place at the University of Pittsburgh Medical Center, with RheOx bronchial rheoplasty procedures performed by Dr. Frank Sciurba and Roy Semaan, the Menlo Park, Calif.-based company said. “We are pleased to partner with Gala in treating the first US patients and thus continuing the contribution of UPMC as a leader in the development of novel devices for our patients with COPD. RheOx offers a potential solution for an unmet need for so many patients who suffer with the persistent symptoms of chronic bronchitis, representing a personalized therapy for our patients with one type of COPD,” UPMC Emphysema/COPD Research Center director Dr. Sciurba said in a prepared statement. The RheOx system is an electrosurgical platform intended to target abnormal, mucus-producing cells in the airways. The system includes a catheter, designed to be used alongside an endoscope, to deliver short bursts of electrical energy to the airway walls. The procedure is intended to replace the abnormal cells with new cells that produce less mucus, Gala Therapeutics said. The trial aims to enroll 15 subjects at five U.S. sites, with the procedures performed in two treatment sessions. The first session treats the right lung airways and a second procedure a mont...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Respiratory galatherapeutics Source Type: news

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The device is being trialled on NHS patients with asthma and chronic obstructive pulmonary disease (COPD), a group of lung conditions including emphysema and chronic bronchitis.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CONCLUSION: Animal production work, including insecticide use, was positively associated with chronic bronchitis symptoms; but not consistently with COPD diagnosis alone. Our results support the need for further investigation into the role of animal production-related exposures in the etiology of COPD and better respiratory protection for agricultural workers. PMID: 31029031 [PubMed - as supplied by publisher]
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
Abstract Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that is influenced by both genetic and environmental factors. For many years, knowledge of the genetic basis of COPD was limited to Mendelian syndromes, such as alpha-1 antitrypsin deficiency and cutis laxa, caused by rare genetic variants. Fortunately, over the past decade, the proliferation of genome-wide association studies (GWAS), the accessibility of whole genome sequencing, and the development of novel methods for analyzing genetic variation data have led to a substantial increase in our understanding of genetic variant...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
JACKSONVILLE, Fla. -- Mayo Clinic in Florida is the first medical center in the state to perform endoscopic lung volume reduction with endobronchial valves. This procedure, which recently was approved by the Food and Drug Administration (FDA), treats patients experiencing disorders associated with chronic obstructive pulmonary disease (COPD), including advanced emphysema and chronic bronchitis. Only [...]
Source: Mayo Clinic Florida News - Category: Hospital Management Source Type: news
Based on the results of a cross-sectionalstudy showing an association between using e-cigarettes and reporting that one has ever been told they have COPD (chronic obstructive lung disease), a number of researchers have essentially concluded that vaping causes COPD, and one researcher is telling the public that use of e-cigarettes increases one's risk of COPDjust like cigarettes.The paper, published inDrug and Alcohol Dependence, reports the results of a cross-sectional study based on the 2016 Behavioral Risk Factor Surveillance System (BRFSS) survey in Hawaii. The outcome variable was reporting ever having been told that o...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
We describe the overdiagnosis and the prevalence of spirometrically defined false positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries participating in the BOLD Study between 2003-2012. METHODS: A false positive diagnosis of COPD was considered when participants reported a doctor's diagnosis of COPD, but post-bronchodilator spirometry was unobstructed (FEV1/FVC>LLN). Additional analyses were performed using the fixed ratio criterion (FEV1/FVC
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Purpose of review Chronic obstructive pulmonary disease is a heterogeneous syndrome associated with varying degrees of parenchymal emphysema and airway inflammation resulting in decreased expiratory flow, lung hyperinflation, and symptoms leading to decreased exercise tolerance and quality of life. Impairment in lung function and quality of life persists following guideline-based medical therapy, thus surgical and minimally invasive bronchoscopic approaches were developed to address this unmet need. We offer a narrative review of the available technologies. Recent findings Although lung volume reduction surgery has be...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: OBSTRUCTIVE, OCCUPATIONAL AND ENVIRONMENTAL DISEASES: Edited by Manish Joshi and Basil Varkey Source Type: research
Major symptoms of chronic obstructive pulmonary disease (COPD) are chronic bronchitis and emphysema leading from lung tissue destruction, that is an effect of an imbalance between metalloproteinases (MMPs) and...
Source: BMC Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
DEAR MAYO CLINIC:?A family friend was recently diagnosed with emphysema, but he never smoked and was told that his condition was caused by alpha-1. What is this, and how is it diagnosed? ANSWER: Emphysema?is one of a group of lung diseases, including chronic bronchitis, that make up chronic obstructive pulmonary disease, or COPD. Tobacco smoking [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
Conclusion: The results from this study will provide information to aid the development of prevention and intervention strategies for Aboriginal communities. PMID: 30584428 [PubMed - in process]
Source: Journal of Environmental and Public Health - Category: Environmental Health Tags: J Environ Public Health Source Type: research
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