Gala Therapeutics launches RheOx chronic bronchitis trial

Gala Therapeutics said today that it launched an early feasibility study of its RheOx system for treating chronic bronchitis, and that the first two patients in the trial have already been enrolled. Initial patient enrollment took place at the University of Pittsburgh Medical Center, with RheOx bronchial rheoplasty procedures performed by Dr. Frank Sciurba and Roy Semaan, the Menlo Park, Calif.-based company said. “We are pleased to partner with Gala in treating the first US patients and thus continuing the contribution of UPMC as a leader in the development of novel devices for our patients with COPD. RheOx offers a potential solution for an unmet need for so many patients who suffer with the persistent symptoms of chronic bronchitis, representing a personalized therapy for our patients with one type of COPD,” UPMC Emphysema/COPD Research Center director Dr. Sciurba said in a prepared statement. The RheOx system is an electrosurgical platform intended to target abnormal, mucus-producing cells in the airways. The system includes a catheter, designed to be used alongside an endoscope, to deliver short bursts of electrical energy to the airway walls. The procedure is intended to replace the abnormal cells with new cells that produce less mucus, Gala Therapeutics said. The trial aims to enroll 15 subjects at five U.S. sites, with the procedures performed in two treatment sessions. The first session treats the right lung airways and a second procedure a mont...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Respiratory galatherapeutics Source Type: news

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Airway cilia dysfunction, either acquired or inborn, results in respiratory diseases e.g. chronic bronchitis. The miR449 cluster is strongly expressed in airway epithelia. Here we show that miR449 knockout (KO) mice develop spontaneous COPD as do wildtypes exposed to cigarette smoke for 6 months, with increased BAL and M2A macrophages. Bacterial challenge leads to increased MMP9 and MMP12 in miR449KO, thus explaining matrix degradation. However, young, naive miR449KO mice do not display any sign of emphysema suggesting that it is a secondary phenotype. miR449KO mice display reduced mucociliary clearance and cilia ultrastru...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway Cell Biology and Immunopathology Source Type: research
Conclusion: The presence of significant co-morbidities can be associated with any clinical phenotype. Known of co-morbidities related to certain phenotype can improve therapy and prognosis of diseases.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusions: Disease severity: 73.7%(479) had at least 1 exacerbation/year, 28.2% received antibiotic treatment, 7% presented to the emergency room, 2.7% required hospitalization. The main reason behind screening spirometry is to provide the millions of people with the right treatment and spread awareness about it.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring Airway Disease Source Type: research
Introduction: Changes in nutritional status are frequently seen in chronic respiratory pts and are considered as comorbidities. Overweight pts have better prognosis than cachectic pts. Mid-thigh fat (MTF) is more used for assessment than peritoneal fat (PF).Aims and objectives: If any correlation between peritoneal fat and mid-thigh fat in a lot of 24 consecutive chronic respiratory pts.Methods: 24 chronic respiratory pts (mean age 62.87; SD 13.05; M 11/45.8%; F 13/54.2%; ; IFP 13/54.2%; COPD 5/20.8%; chronic bronchitis 4/16.7%; emphysema 1/4.2%; TB sequela 1/4.2%) were evaluated for age, gender, body mass index, waist-to-...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Introduction: Chronic obstructive pulmonary disease (COPD) may have serious manifestation and an impact on the functional situation of the severe patients.Objective: to characterize patients with severe COPD (BODE index ≥ 7) attended in outpatients pulmonary clinics. Material and methods: Cross-sectional descriptive study carried out in 7 hospitals in Spain. Stable COPD patients with a BODE ≥ 7. The variables studied were: sociodemographics, clinical, comorbidities, symptoms, exacerbations, quality of life, depression, anxiety, physical activity and degree of dependency.Results: 51 patients (75.3 (± 5.8) yrs, ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
CONCLUSION: The announcement of the disease did not always appear to have been of good quality. Ideally, the diagnosis of COPD should be conveyed to people after its identification in a dedicated consultation, combined with better information and a proposal for psychological support. PMID: 30415820 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
García-Barrera T Abstract The high prevalence of lung cancer (LC) has triggered the search of biomarkers for early diagnosis of this disease. For this purpose the study of metabolic changes related to the development of lung cancer could provide interesting information about its early diagnosis. In this sense, chronic obstructive pulmonary disease (COPD), a disease associated with tumor development, is a comorbidity that increases the risk of onset and progression of lung neoplasia and has also to be considered in the study of pathology related to lung cancer. This work develop a metabolomic approach based ...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
COPD, which is often linked to smoking, is a progressive deterioration of lung function that involves a combination of bronchitis and emphysema symptoms.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Authors: Welling JBA, Slebos DJ Abstract The lung volume reduction coil treatment is a minimally invasive bronchoscopic treatment option for emphysema patients who suffer from severe hyperinflation. The treatment is aimed at a large group of patients where lung volume reduction surgery and bronchoscopic lung volume reduction using endobronchial valves are no option, or alternatively, can be offered as a bridge to lung transplantation. The nitinol coil exhibits a shape memory effect and is biologically inert. The lung volume reduction coil procedure is performed in two separate treatment sessions, targeting one lobe...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Martini K, Frauenfelder T Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide. One of the main findings is pulmonary emphysema in association with chronic bronchitis. Clinical signs, pulmonary function tests and imaging are the current used methods to diagnose and stage emphysema. Lung volume reduction (LVR) and endoscopic lung volume reduction (ELVR) are the current therapeutic options beside lung transplantation in cases of severe emphysema. Nowadays imaging is one of the key factors for the success of these therapies. Especially quantitative computed tom...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
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