NICE should change antibiotic guidelines for dental patients -- study shows
(University of Sheffield) New research has revealed the impact a change in US guidelines had on the prescribing of antibiotic prophylaxis (AP) to prevent a life-threatening heart condition infective endocarditis (IE) in patients before undergoing invasive dental treatment.
CONCLUSION: In patients with vascular prostheses, Propionibacterium acnes infection must be evoked face to an atypical inflammatory process. Very prolonged blood culture incubation is needed to identify the pathogen. PMID: 31229357 [PubMed - as supplied by publisher]
This study aimed to define the impact of DM on long-term mortality in IE patients. A total of 412 patients with definite IE from February 1999 to June 2012 were enrolled in this observational study and divided into 2 groups: group 1, patients with DM (n = 72) and group 2, patients without DM (n = 340). The overall in-hospital mortality rate for both groups combined was 20.2% and was higher in group 1 than in group 2 (41.7% vs. 16.5%, p < 0.01). Compared to patients without DM, patients with DM were older and associated with higher incidence of chronic diseases, less drug abuse, higher creatinine levels, and increase...
Background: Infective endocarditis (IE) is a serious illness with high morbidity and mortality. There is a need for early recognition of patients at risk of adverse events to guide management decisions and improve outcomes. Recent studies have identified inflammatory biomarkers including C-reactive protein (CRP), neutrophil-to-lymphocyte-ratio (NLR), and platelet-to-lymphocyte ratio (PLR) as prognostic factors in IE. We sought to identify simple laboratory parameters in IE patients as predictors of in-hospital mortality in our centre.
Background: Infective Endocarditis (IE) is a common pathology requiring admission to hospital. The length of stay in these patients can often be prolonged due to the need for prolonged courses of intravenous antibiotics. This can be associated with poor outcomes for the patient due to medical complications of prolonged hospital stay as well as increase the costs to the healthcare system. One way of reducing length of stay is utilising hospital in the home (HITH) services for administration of intravenous antibiotics in patients who are otherwise stable and can be discharged home safely, but still require completion of seve...
Background: The ANZ population undergoing PPVI, including short to medium term outcomes, has not been fully characterised. In particular, there are concerns about infective endocarditis (IE) risk.
This study aimed to characterise the frequency of embolisation in PVE versus native valve endocarditis (NVE) and delay in surgery as a result of emboli.
Introduction: Hospital in the Home (HITH) plays an important role in the treatment of infective endocarditis (IE) in Australia. To date, there are no published data on the current activity and outcomes of HITH in IE.
In this study we explored the biological role of the capsule ofE. faecium. Our findings showed that the U0317 strain is not only sensitive to anti-LTA but also to antibodies against other enterococcal surface proteins. Our findings demonstrate that polysaccharides capsule mediated-resistance to opsonophagocytosis. We also found that the capsular polysaccharides do not play an important role in bacterial virulence in urinary tract and infective endocarditisin vivo models.
AbstractPurpose of ReviewInfective endocarditis (IE) is a significant risk and complication in patients with a history of intravenous (IV) drug use (DU), and treatments are becoming more invasive as infections become more serious. IV drug use is an extremely addictive behavior and challenging behavior to address, and patients are at high risk of relapse to IV drug use even after successful IE treatment. Addressing the underlying cause with behavioral modification is essential to prevent behavior and subsequent infection recurrence. Treatments depend on a multidisciplinary approach to address the physiologic and underlying ...
Little is known about the subsequent risk of stroke and recurrence of IE for patients surviving infective endocarditis (IE) with a residual vegetation at discharge.