The therapeutic potential of aqueous extract of Falcaria vulgaris in the treatment of fatty liver disease: a histopathological and biochemical approach

In this study, we assessed the potential of aqueous extract ofFalcaria vulgaris in treatment of fatty liver disease by investigating the histopathological and biochemical approaches. In beginning of the research, a total of 10 Wistar male rats were selected as the negative healthy control, and 50 rats were treated with a high-fat diet for 4  months. Then, the animals were randomly divided into six subgroups, including negative healthy control group, untreated group, and four groups receiving the aqueous extract ofF. vulgaris at 25, 50, 100, and 200-mg/kg concentrations. After 2  months, the rats were sacrificed, and blood and liver samples of them were collected to analyze the histopathological and biochemical parameters. The data were analyzed by SPSS-21 software. Different groups ofF. vulgaris significantly (p ≤ 0.05) decreased the increased concentrations of ALP (alkaline phosphatase), AST (aspartate transaminase), ALT (alanine aminotransferase), GGT (gamma-glutamyl transferase), cholesterol, LDL (low-density lipoprotein), triglyceride, total and conjugated bilirubin, glucose, and GR (glutathione reductase) and enhanced the concentrations of HDL (high-density lipoprotein), total protein, albumin, SOD (superoxide dismutase), CAT (catalase), and GPx (glutathione peroxidase) as compared to the untreated group. Also,F. vulgaris reduced the degree of hepatic steatosis as compared to the untreated group. It appears that the aqueous extract ofF. vulgari...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Nutrition and Metabolism - Category: Nutrition Authors: Tags: Research Source Type: research
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Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - Category: Physiology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
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Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
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Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
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Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Research Source Type: research
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