Cancers, Vol. 10, Pages 422: Targeting the Hippo Pathway for Breast Cancer Therapy

Cancers, Vol. 10, Pages 422: Targeting the Hippo Pathway for Breast Cancer Therapy Cancers doi: 10.3390/cancers10110422 Authors: Liqing Wu Xiaolong Yang Breast cancer (BC) is one of the most prominent diseases in the world, and the treatments for BC have many limitations, such as resistance and a lack of reliable biomarkers. Currently the Hippo pathway is emerging as a tumor suppressor pathway with its four core components that regulate downstream transcriptional targets. In this review, we introduce the present targeted therapies of BC, and then discuss the roles of the Hippo pathway in BC. Finally, we summarize the evidence of the small molecule inhibitors that target the Hippo pathway, and then discuss the possibilities and future direction of the Hippo-targeted drugs for BC therapy.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research