S-ketamine reduces marble burying behaviour: involvement of ventromedial orbitofrontal cortex and AMPA receptors.
In conclusion, the reduction of MBB by S-ketamine strengthens its possible anti-compulsive effect. The vmOFC is involved in this S-ketamine effect, which is dependent on the activation of AMPA receptors.
PMID: 30385254 [PubMed - as supplied by publisher]
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tosta CL, Silote GP, Fracalossi MP, Sartim AG, Andreatini R, Lourenço Joca SR, Beijamini V Tags: Neuropharmacology Source Type: research