A retrospective study of extracolonic, non-endometrial cancer in Swedish Lynch syndrome families.
Conclusion: Lynch syndrome confers an increased risk for multiple cancers other than colorectal and endometrial cancer. The proportions of other cancers vary between different MMR genes, with highest frequency in MSH2-carriers. Gender and age also affect the tumour spectrum, demonstrating the importance of additional environmental and constitutional parameters in determining the predisposition for different cancer types.
PMID: 30386444 [PubMed]
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Karimi M, von Salomé J, Aravidis C, Silander G, Askmalm MS, Henriksson I, Gebre-Medhin S, Frödin JE, Björck E, Lagerstedt-Robinson K, Lindblom A, Tham E Tags: Hered Cancer Clin Pract Source Type: research
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