Vasodilatory Effects of Aloperine in Rat Aorta and Its Possible Mechanisms.
In this study, aloperine caused concentration-dependent relaxations in
aortic rings precontracted with phenylephrine, but this effect was not observed in KCl-pretreated
rings. Removal of endothelium showed no influence on vasodilatory effects of aloperine. In
addition, preincubation with NG-nitro-L-arginine methylester and indomethacin did not inhibit the
vasodilatory effects of aloperine, suggesting that the vasodilative action is endothelium-independent.
Relaxant responses to aloperine were inhibited by tetraethylammonium and 4-aminopyridine.
However, the vasorelaxant effect of aloperine was also not influenced by the preincubation with BaClâ‚‚
and glibenclamide. These findings suggest that aloperine-induced vasorelaxation effects are mainly
due to the operations of voltage-operated potassium channels and ATP-sensitive potassium channels.
PMID: 30384550 [PubMed - as supplied by publisher]
Source: The Chinese Journal of Physiology - Category: Physiology Tags: Chin J Physiol Source Type: research