An integrated approach of bioinformatic prediction and in vitro analysis identified that miR-34a targets MET and AXL in triple-negative breast cancer.
Conclusions: These findings may indicate that miR-34a is an oncogenic miRNA, downregulated in the distinct breast cancer subtypes. It also targets MET and AXL 3'-UTRs in triple-negative breast cancer. Therefore, it can be considered as a therapeutic target in this type of breast cancer.
PMID: 30386383 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Hajalirezay Yazdi S, Paryan M, Mohammadi-Yeganeh S Tags: Cell Mol Biol Lett Source Type: research
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