Potent Anti-adhesion Agent Using a Drug-eluting Visible-light Curable Hyaluronic Acid Derivative

In this study, a visible light-curable furfuryl hyaluronic acid derivative was prepared and combined with ibuprofen for anti-adhesion and anti-inflammatory applications. A furfuryl isocyanate moiety was introduced in hyaluronic acid affording furfuryl hyaluronic acid (F-HA). The anti-adhesion and anti-inflammatory effects of F-HA were examined in chickens at 2, 4, and 8 weeks postoperation. It was concluded that F-HA combined with ibuprofen is a suitable anti-adhesion and anti-inflammation agent.Graphical abstract

Source: Journal of Industrial and Engineering Chemistry - November 3, 2018 Category: Chemistry Source Type: research