Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB
Conclusions
Hypoxia decreases hepatic hepcidin expression by a novel regulatory pathway exerted via PDGF-BB, leading to increased availability of circulating iron that can be used for erythropoiesis.
Source: Gut - Category: Gastroenterology Authors: Sonnweber, T., Nachbaur, D., Schroll, A., Nairz, M., Seifert, M., Demetz, E., Haschka, D., Mitterstiller, A.-M., Kleinsasser, A., Burtscher, M., Trubsbach, S., Murphy, A. T., Wroblewski, V., Witcher, D. R., Mleczko-Sanecka, K., Vecchi, C., Muckenthaler, M Tags: Hepatology Source Type: research
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