The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands

Conclusions
Barrett's shows the proliferative and stem cell architecture, and pattern of gene expression of pyloric gastric glands, maintained by stem cells showing gastric and intestinal differentiation: neutral drift may suggest that intestinal differentiation advances with time, a concept critical for the understanding of the origin and development of Barrett's oesophagus.

Source: Gut - October 31, 2014 Category: Gastroenterology Authors: Lavery, D. L., Nicholson, A. M., Poulsom, R., Jeffery, R., Hussain, A., Gay, L. J., Jankowski, J. A., Zeki, S. S., Barr, H., Harrison, R., Going, J., Kadirkamanathan, S., Davis, P., Underwood, T., Novelli, M. R., Rodriguez-Justo, M., Shepherd, N., Jansen, Tags: Open access, Oesophageal cancer Oesophagus Source Type: research