Prevalence and distribution of human papillomavirus genotypes among women with high ‐grade squamous intraepithelial lesion and invasive cervical cancer in Ganzhou, China
Journal of Clinical Laboratory Analysis, EarlyView.
Publication date: Available online 20 February 2019Source: BiologicalsAuthor(s): Gordana Kovacevic, Vesna Milosevic, Petar Knezevic, Aleksandra Knezevic, Ivana Knezevic, Jelena Radovanov, Natasa Nikolic, Aleksandra Patic, Vladimir Petrovic, Ivana Hrnjakovic Cvjetkovic, Ljiljana StanisicAbstractThe main purpose of this paper is to estimate the pre-vaccination prevalence of 12 hrHPV types among 564 women from Vojvodina province (Serbia). The corrected contingency coefficient (Ccorr) was used to estimate the importance of association of examined HPV types and cytological diagnosis. The highest association with the abnormal cy...
More than 44 million women could be diagnosed with cervical cancer in the next 50 years if high coverage human papillomavirus vaccination and cervical screening cannot be achieved globally, a modelling study published in The Lancet Oncology has found.
Introduction: Programmed cell death 1 (PD-1) and its ligand PD-L1 have an important function in the maintenance of the immune homeostasis. PD-1 as the inhibitory checkpoint controls damage of the healthy tissues during infection and promotes self-tolerance. High PD-1 expression on the surface of T cells changes its ability to eliminate of cancer and infectious disease. Cervical intraepithelial neoplasia is a premalignant transformation associated with infection with oncogenic types of HPV human papillomavirus, which is a direct precursor to cervical cancer.
Introduction: Human papillomavirus (HPV) is a virus that can cause various disease states including genital or venereal warts, benign growths (papillomas), cancers, or more commonly, transient infections. Almost 100% of all cervical cancer cases are caused by HPV. HPV vaccination can reduce the risk of infection.
Introduction: The International Agency for Research on Cancer has established strong evidence for the causal aetiology of HPV and cancers of the cervix uteri, vulva, vagina (HPV Information Centre, 2016).
Introduction: The vaginal microbiome plays a significant role in the maintenance of health and occurrence of disease in the female lower genital tract. Human papillomavirus (HPV) causes cervical intraepithelial neoplasia and cervical and vaginal cancer.
(American Society for Microbiology) Infections with a Human Papillomavirus (HPV) cause 99 percent of cervical cancer cases, and the disease's first sign is often the appearance of precancerous lesions on a woman's cervix. But bacteria may play an important role, too. New research suggests that the cervical microbiome may influence HPV infection more than researchers previously thought.
Persistent high-risk human papillomavirus (HPV) infection has been associated with increased risk for cervical precancerous lesions and cancer. The host ’s genetic variability is known to play a role in the development of cervical cancer. The human leukocyte antigen (HLA) genes are highly polymorphic and have shown to be important risk determinants of HPV infection persistence and disease progression. HLA class I and II cell surface molecules regu late the host’s immune system by presenting HPV-derived peptides to T-cells. The activation of T-cell response may vary depending on the HLA allele polymorphism. The ...
ConclusionsThe general public was moderately aware of human papillomavirus, but associated human papillomavirus with cervical cancer. Knowledge of non-cervical human papillomavirus–related cancers is low, even among vaccine-eligible subgroups. Public health education is needed to raise awareness of non-cervical human papillomavirus–related cancers.
UCLA Health Rates of sexually transmitted diseases have risen for the past four years to record highs in the United States, according to the Centers for Disease Control and Prevention ’slatest analysis. In California, the state health departmentfound that the number of people diagnosed with syphilis, gonorrhea or chlamydia in 2017 was 45 percent higher than five years prior.These sorts of statistics may spark a fear that there ’s little we can do to protect ourselves — but that’s not the full story.Dr. Leena Nathan, an obstetrician/gynecologist at UCLA Health-Westlake Village, consults with peo...