Low serum adiponectin is a predictor of progressing to nonalcoholic fatty liver disease

Journal of Clinical Laboratory Analysis, EarlyView.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Source Type: research

Related Links:

David Porras, Esther Nistal, Susana Mart ínez-Flórez, Javier González-Gallego, María Victoria García-Mediavilla, Sonia Sánchez-Campos
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Goals/Background: We aimed to assess temporal changes in the different types of liver disease (LD) cases and outcomes from emergency departments (EDs) across the United States. Study: We used data from the National Inpatient Survey database from 2005 to 2011. The International Classification of Diseases, Ninth Revision (ICD-9) clinical modification codes identified hepatitis C virus (HCV), hepatitis B virus (HBV), alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), and other LDs including autoimmune hepatitis. We excluded cases without LD, nonhepatocellular carcinoma–related cancers, human i...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD, Published online: 17 December 2018; doi:10.1038/s41575-018-0094-6In 2018, there have been substantial advances in our understanding of the risk factors for advanced liver disease in nonalcoholic fatty liver disease, including genetic variants and the gut microbiota. Promising results have also arisen from drugs targeting metabolic pathways involved in the progression of liver damage.
Source: Nature Reviews Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Hepatocellular Carcinoma (HCC) is a common cause of cancer-related deaths with increasing mortality worldwide [1]. In western societies, 30-40% of HCC patients are obese and have nonalcoholic steatohepatitis (NASH), an aggressive form of nonalcoholic fatty liver disease (NAFLD)[2 –5]. Abnormal lipid accumulation in hepatocytes increases oxidative stress and leads to lipotoxicity, which triggers liver inflammation, a hallmark in NAFLD progression to HCC[6]. Pro-tumorigenic subsets of neutrophils, macrophages, and other immune cells provide the tumor microenvironment (TME) w ith growth factors, matrix-remodeling factor...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Authors: Karczewski J, Śledzińska E, Baturo A, Jończyk I, Maleszko A, Maleszko A, Samborski P, Begier-Krasińska B, Dobrowolska A Abstract The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence points to localized inflammation in adipose tissue, which, in turn, promotes systemic low-grade inflammation as a primary force contributing to the d...
Source: European Cytokine Network - Category: Molecular Biology Tags: Eur Cytokine Netw Source Type: research
Publication date: Available online 15 December 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Qinling Pan, Tingfeng Qin, Yuan Gao, Shaojian Li, Danjie Li, Miao Peng, Hening Zhai, Geyang XuAbstractRoux-en-Y Gastric Bypass (RYGB) remains one of the most effective options in treatment of non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms are not clear yet. Here, we evaluated the relationship among hepatic mechanistic target of rapamycin (mTOR)-AKT2-insulin-induced gene 2 (Insig2) signaling, lipogenic transcription factors and lipid synthesis enzymes in obese m...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
(Natural News) Nonalcoholic fatty liver disease is not a serious condition in itself, but its complications can be deadly. The extract of Asian water plantains (Alisma orientale) could be a potential treatment for the condition, according to a study in BMC Complementary and Alternative Medicine, as it is able to not only reduce the amount of...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conclusions Resveratrol is a promising agent for the treatment of hyperuricemia-related NAFLD through activating SIRT1 pathways.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: This beneficial effect could be helpful in the treatment of NAFLD. PMID: 30522586 [PubMed - in process]
Source: J Pharm Pharm Sci - Category: Drugs & Pharmacology Authors: Tags: J Pharm Pharm Sci Source Type: research
More News: Fatty Liver Disease (FLD) | Laboratory Medicine | Liver | Liver Disease | Non-alcoholic Fatty Liver Diseases (NAFLD) | Urology & Nephrology