LMO2 functional and transcriptional regulatory profiles in hematopoietic cells

The human lmo2 gene was first cloned from acute T lymphocytic leukemia (T-ALL) patients [1,2]. It is expressed in a variety of tissues with the highest in hematopoietic stem/progenitor cells [3]. However, LMO2 expression during thymocyte development was specifically turned off, and ectopic expression of LMO2 caused T-cell development arrest and T cell leukemia [4,5]. LMO2 consists of only two tandem LIM domains, lacks direct DNA-binding capacity and always acts as a bridging or blocking molecular via protein-protein interactions [4,6].
Source: Leukemia Research - Category: Hematology Authors: Tags: Correspondence Source Type: research