Uncoupling Protein 2 (UCP2) as Genetic Risk Factor for Obesity in Indonesia is Different in Gender Stratification.

This study consisted of 200 Indonesian subjects of Javanese ethnicity consisting of 100 obese and 100 non-obese participants. Examination of Ala55Val (C > T) UCP2 genotype used Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) methods and 45 bp I/D genotype used PCR methods. Polymorphism of Ala55Val UCP2 genotype in the male group showed that TT genotype and T allele significantly lowers the risk of obesity. Insertion/deletion of 45 bp UCP2 gene in the male group showed that II genotype and I allele significantly increase the risk of obesity whereas for women it showed that the DI genotype and I allele lower the risk of obesity. The results of this study demonstrate that Ala55Val and 45 bp I/D UCP2 polymorphisms play a role in the risk of obesity in Javanese ethnicity of Indonesia after gender stratification. PMID: 30381728 [PubMed - in process]
Source: Kobe J Med Sci - Category: General Medicine Authors: Tags: Kobe J Med Sci Source Type: research